Association between breast cancer and thyroid cancer: A study based on 13 978 patients with breast cancer

Nai si Huang, Xing xing Chen, Wen jun Wei, Miao Mo, Jia ying Chen, Ben Ma, Shu wen Yang, Wei bo Xu, Jiong Wu, Qing hai Ji, Xiao mao Guo, Guang yu Liu, Zhi min Shao, Yu Wang

Research output: Contribution to journalArticle

Abstract

Background: Thyroid cancer (TC) is one of the most commonly seen secondary malignancy in breast cancer (BC) survivors. Materials and methods: A retrospective study was conducted in BC patients in our center from 1999 to 2013. Patients were divided into BC-TC group and BC-alone group. Results: In total, 13 978 BC patients were identified, among whom 247 (1.8%) had TC. The standardized incidence ratio (SIR) of TC was 4.48 compared with Chinese females, and up to 98.0% of cases were thyroid papillary carcinomas. A family history of malignancy was the only independent risk factor (odds ratio = 1.457, P = 0.025) for development of TC in patients with BC. We also identified inferior survival in patients with synchronous versus metachronous BC-TC (P = 0.016). Synchronous BC-TC (risk ratio = 5.597, P = 0.018) was an independent prognostic factor for inferior RFS. Conclusions: We observed high co-occurrence of TC in patients with BC. There might be different mechanisms behind synchronous and metachronous BC-TC.

Original languageEnglish (US)
Pages (from-to)6393-6400
Number of pages8
JournalCancer medicine
Volume7
Issue number12
DOIs
StatePublished - Dec 2018

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Thyroid Neoplasms
Breast Neoplasms
Odds Ratio
Survivors
Neoplasms
Retrospective Studies

Keywords

  • breast cancer
  • prognosis
  • second primary malignancy
  • synchronous cancer
  • thyroid cancer

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Huang, N. S., Chen, X. X., Wei, W. J., Mo, M., Chen, J. Y., Ma, B., ... Wang, Y. (2018). Association between breast cancer and thyroid cancer: A study based on 13 978 patients with breast cancer. Cancer medicine, 7(12), 6393-6400. https://doi.org/10.1002/cam4.1856

Association between breast cancer and thyroid cancer : A study based on 13 978 patients with breast cancer. / Huang, Nai si; Chen, Xing xing; Wei, Wen jun; Mo, Miao; Chen, Jia ying; Ma, Ben; Yang, Shu wen; Xu, Wei bo; Wu, Jiong; Ji, Qing hai; Guo, Xiao mao; Liu, Guang yu; Shao, Zhi min; Wang, Yu.

In: Cancer medicine, Vol. 7, No. 12, 12.2018, p. 6393-6400.

Research output: Contribution to journalArticle

Huang, NS, Chen, XX, Wei, WJ, Mo, M, Chen, JY, Ma, B, Yang, SW, Xu, WB, Wu, J, Ji, QH, Guo, XM, Liu, GY, Shao, ZM & Wang, Y 2018, 'Association between breast cancer and thyroid cancer: A study based on 13 978 patients with breast cancer', Cancer medicine, vol. 7, no. 12, pp. 6393-6400. https://doi.org/10.1002/cam4.1856
Huang, Nai si ; Chen, Xing xing ; Wei, Wen jun ; Mo, Miao ; Chen, Jia ying ; Ma, Ben ; Yang, Shu wen ; Xu, Wei bo ; Wu, Jiong ; Ji, Qing hai ; Guo, Xiao mao ; Liu, Guang yu ; Shao, Zhi min ; Wang, Yu. / Association between breast cancer and thyroid cancer : A study based on 13 978 patients with breast cancer. In: Cancer medicine. 2018 ; Vol. 7, No. 12. pp. 6393-6400.
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