Association between dietary factors and breast cancer risk among chinese females: Systematic review and meta-analysis

Xue Ou Liu, Yu Bei Huang, Ying Gao, Chuan Chen, Ye Yan, Hong Ji Dai, Feng Ju Song, Yao Gang Wang, Pei Shan Wang, Ke Xin Chen

    Research output: Contribution to journalArticle

    24 Scopus citations

    Abstract

    Background: Evidence for associations between dietary factors and breast cancer risk is inconclusive among Chinese females. To evaluate this question, we conducted a systematic review of relevant case-control and cohort studies. Methods: Studies were systematically searched among 5 English databases (PudMed, ScienceDirect, Wiley, Clinicaltrials.gov, and Cochrane) and 3 Chinese databases (CNKI, WanFang, and VIP) until November 2012. Random effects models were used to estimate summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). Results: Thirty one case-control studies and two cohort studies involving 9,299 cases and 11,413 controls were included. Consumption of both soy and fruit was significantly associated with decreased risk of breast cancer, with summary ORs of 0.65 (95% CIs: 0.43-0.99; I2=88.9%, P<0.001; N=13) and 0.66 (95% CIs: 0.47-0.91; I2=76.7%, P<0.001; N=7), respectively. Consumption of fat was significantly associated with increased risk of breast cancer (OR=1.36; 95% CIs: 1.13-1.63; I2=47.9%, P=0.088; N=6). There was non-significant association between consumption of vegetables and breast cancer risk (OR=0.72; 95% CIs: 0.51-1.02; I2= 74.4%, P<0.001; N=9). However, sensitivity analysis based on adjusted ORs showed decreased risk of breast cancer was also associated with consumption of vegetables (OR=0.49; 95% CIs: 0.30-0.67). Conclusion: Both soy food and fruit are significantly associated with decreased risk of breast cancer among Chinese females, and vegetables also seems to be protective while dietary fatexerts a promoting influence.

    Original languageEnglish (US)
    Pages (from-to)1291-1298
    Number of pages8
    JournalAsian Pacific Journal of Cancer Prevention
    Volume15
    Issue number3
    DOIs
    StatePublished - 2014

      Fingerprint

    Keywords

    • Breast cancer
    • Fat
    • Fruit
    • Meta-analysis
    • Soy
    • Vegetable

    ASJC Scopus subject areas

    • Epidemiology
    • Oncology
    • Public Health, Environmental and Occupational Health
    • Cancer Research

    Cite this

    Liu, X. O., Huang, Y. B., Gao, Y., Chen, C., Yan, Y., Dai, H. J., Song, F. J., Wang, Y. G., Wang, P. S., & Chen, K. X. (2014). Association between dietary factors and breast cancer risk among chinese females: Systematic review and meta-analysis. Asian Pacific Journal of Cancer Prevention, 15(3), 1291-1298. https://doi.org/10.7314/APJCP.2014.15.3.1291