Association of neurologic deficits with surgical outcomes and health-related quality of life after treatment for metastatic epidural spinal cord compression

for the AOSpine Knowledge Forum Tumor

doi:10.1002/cncr.32420

Association of neurologic deficits with surgical outcomes and health-related quality of life after treatment for metastatic epidural spinal cord compression

for the AOSpine Knowledge Forum Tumor

Neurosurgery

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Background: A critical knowledge gap exists regarding the impact of neurologic deficits on surgical outcomes and health-related quality of life (HRQOL) for patients surgically treated for metastatic epidural spinal cord compression (MESCC). Methods: This prospective, multicenter and international study analyzed the impact of the neurologic status on functional status, HRQOL, and postoperative survival. The collected data included the patient demographics, overall survival, American Spinal Injury Association (ASIA) impairment scale, Spinal Instability Neoplastic Score, treatment details and complications and HRQOL measures, including version 2 of the 36-Item Short Form Health Survey (SF-36v2) and version 2.0 of the Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ2.0). Results: A total of 239 patients surgically treated for spinal metastases were included. Six weeks after treatment, 99 of the 108 patients with a preoperative ASIA grade of E remained stable, 8 deteriorated to ASIA D, and 1 deteriorated to ASIA A. Of 55 patients with ASIA D, 27 improved to ASIA E, 27 remained stable and 1 deteriorated to ASIA C. Of 11 patients with ASIA A to C, 2 improved to ASIA E, 4 improved to ASIA D, and 5 remained stable. At the 6- and 12-week follow-up, better ASIA scores were associated with better scores on multiple SF-36v2 and SOSGOQ items. Postoperatively, patients with ASIA grades of A to D were more likely to have urinary tract infections and wound complications. Patients with a baseline ASIA grade of E or D survived significantly longer. Conclusions: Patients with neurologic deficits due to MESCC have worse HRQOL and decreased overall survival. Nevertheless, surgery can result in stabilization or improvement of neurologic function which may translate into better HRQOL. Postoperative care and follow-up are challenging for patients with neurologic deficits because they experience more complications.

Original language	English (US)
Pages (from-to)	4224-4231
Number of pages	8
Journal	Cancer
Volume	125
Issue number	23
DOIs	https://doi.org/10.1002/cncr.32420
State	Published - Dec 1 2019

Keywords

health-related quality of life (HRQOL)
neurologic deficit
spine
surgery
treatment
tumor

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/cncr.32420

Cite this

@article{3bdeb826db6a4ef194e20ef60b02e428,

title = "Association of neurologic deficits with surgical outcomes and health-related quality of life after treatment for metastatic epidural spinal cord compression",

abstract = "Background: A critical knowledge gap exists regarding the impact of neurologic deficits on surgical outcomes and health-related quality of life (HRQOL) for patients surgically treated for metastatic epidural spinal cord compression (MESCC). Methods: This prospective, multicenter and international study analyzed the impact of the neurologic status on functional status, HRQOL, and postoperative survival. The collected data included the patient demographics, overall survival, American Spinal Injury Association (ASIA) impairment scale, Spinal Instability Neoplastic Score, treatment details and complications and HRQOL measures, including version 2 of the 36-Item Short Form Health Survey (SF-36v2) and version 2.0 of the Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ2.0). Results: A total of 239 patients surgically treated for spinal metastases were included. Six weeks after treatment, 99 of the 108 patients with a preoperative ASIA grade of E remained stable, 8 deteriorated to ASIA D, and 1 deteriorated to ASIA A. Of 55 patients with ASIA D, 27 improved to ASIA E, 27 remained stable and 1 deteriorated to ASIA C. Of 11 patients with ASIA A to C, 2 improved to ASIA E, 4 improved to ASIA D, and 5 remained stable. At the 6- and 12-week follow-up, better ASIA scores were associated with better scores on multiple SF-36v2 and SOSGOQ items. Postoperatively, patients with ASIA grades of A to D were more likely to have urinary tract infections and wound complications. Patients with a baseline ASIA grade of E or D survived significantly longer. Conclusions: Patients with neurologic deficits due to MESCC have worse HRQOL and decreased overall survival. Nevertheless, surgery can result in stabilization or improvement of neurologic function which may translate into better HRQOL. Postoperative care and follow-up are challenging for patients with neurologic deficits because they experience more complications.",

keywords = "health-related quality of life (HRQOL), neurologic deficit, spine, surgery, treatment, tumor",

author = "{for the AOSpine Knowledge Forum Tumor} and Ori Barzilai and Versteeg, {Anne L.} and Goodwin, {C. Rory} and Arjun Sahgal and Rhines, {Laurence D.} and Sciubba, {Daniel M.} and Schuster, {James M.} and Weber, {Michael H.} and Aron Lazary and Fehlings, {Michael G.} and Clarke, {Michelle J.} and Arnold, {Paul M.} and Stefano Boriani and Chetan Bettegowda and Gokaslan, {Ziya L.} and Fisher, {Charles G.} and Ilya Laufer",

note = "Funding Information: This study was organized and funded by AOSpine International through the AOSpine Knowledge Forum Tumor, a focused group of international spine oncology experts acting on behalf of AOSpine. Study support was provided directly through the AOSpine Research Department and the AO Clinical Investigation and Documentation Unit. A research grant for the current study was received from the Orthopaedic Research and Education Foundation. The University of Texas MD Anderson Cancer Center is supported by the National Institutes of Health (grant P30 CA016672). Publisher Copyright: {\textcopyright} 2019 American Cancer Society",

year = "2019",

month = dec,

day = "1",

doi = "10.1002/cncr.32420",

language = "English (US)",

volume = "125",

pages = "4224--4231",

journal = "Cancer",

issn = "0008-543X",

publisher = "John Wiley and Sons Inc.",

number = "23",

}

TY - JOUR

T1 - Association of neurologic deficits with surgical outcomes and health-related quality of life after treatment for metastatic epidural spinal cord compression

AU - for the AOSpine Knowledge Forum Tumor

AU - Barzilai, Ori

AU - Versteeg, Anne L.

AU - Goodwin, C. Rory

AU - Sahgal, Arjun

AU - Rhines, Laurence D.

AU - Sciubba, Daniel M.

AU - Schuster, James M.

AU - Weber, Michael H.

AU - Lazary, Aron

AU - Fehlings, Michael G.

AU - Clarke, Michelle J.

AU - Arnold, Paul M.

AU - Boriani, Stefano

AU - Bettegowda, Chetan

AU - Gokaslan, Ziya L.

AU - Fisher, Charles G.

AU - Laufer, Ilya

N1 - Funding Information: This study was organized and funded by AOSpine International through the AOSpine Knowledge Forum Tumor, a focused group of international spine oncology experts acting on behalf of AOSpine. Study support was provided directly through the AOSpine Research Department and the AO Clinical Investigation and Documentation Unit. A research grant for the current study was received from the Orthopaedic Research and Education Foundation. The University of Texas MD Anderson Cancer Center is supported by the National Institutes of Health (grant P30 CA016672). Publisher Copyright: © 2019 American Cancer Society

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Background: A critical knowledge gap exists regarding the impact of neurologic deficits on surgical outcomes and health-related quality of life (HRQOL) for patients surgically treated for metastatic epidural spinal cord compression (MESCC). Methods: This prospective, multicenter and international study analyzed the impact of the neurologic status on functional status, HRQOL, and postoperative survival. The collected data included the patient demographics, overall survival, American Spinal Injury Association (ASIA) impairment scale, Spinal Instability Neoplastic Score, treatment details and complications and HRQOL measures, including version 2 of the 36-Item Short Form Health Survey (SF-36v2) and version 2.0 of the Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ2.0). Results: A total of 239 patients surgically treated for spinal metastases were included. Six weeks after treatment, 99 of the 108 patients with a preoperative ASIA grade of E remained stable, 8 deteriorated to ASIA D, and 1 deteriorated to ASIA A. Of 55 patients with ASIA D, 27 improved to ASIA E, 27 remained stable and 1 deteriorated to ASIA C. Of 11 patients with ASIA A to C, 2 improved to ASIA E, 4 improved to ASIA D, and 5 remained stable. At the 6- and 12-week follow-up, better ASIA scores were associated with better scores on multiple SF-36v2 and SOSGOQ items. Postoperatively, patients with ASIA grades of A to D were more likely to have urinary tract infections and wound complications. Patients with a baseline ASIA grade of E or D survived significantly longer. Conclusions: Patients with neurologic deficits due to MESCC have worse HRQOL and decreased overall survival. Nevertheless, surgery can result in stabilization or improvement of neurologic function which may translate into better HRQOL. Postoperative care and follow-up are challenging for patients with neurologic deficits because they experience more complications.

AB - Background: A critical knowledge gap exists regarding the impact of neurologic deficits on surgical outcomes and health-related quality of life (HRQOL) for patients surgically treated for metastatic epidural spinal cord compression (MESCC). Methods: This prospective, multicenter and international study analyzed the impact of the neurologic status on functional status, HRQOL, and postoperative survival. The collected data included the patient demographics, overall survival, American Spinal Injury Association (ASIA) impairment scale, Spinal Instability Neoplastic Score, treatment details and complications and HRQOL measures, including version 2 of the 36-Item Short Form Health Survey (SF-36v2) and version 2.0 of the Spine Oncology Study Group Outcomes Questionnaire (SOSGOQ2.0). Results: A total of 239 patients surgically treated for spinal metastases were included. Six weeks after treatment, 99 of the 108 patients with a preoperative ASIA grade of E remained stable, 8 deteriorated to ASIA D, and 1 deteriorated to ASIA A. Of 55 patients with ASIA D, 27 improved to ASIA E, 27 remained stable and 1 deteriorated to ASIA C. Of 11 patients with ASIA A to C, 2 improved to ASIA E, 4 improved to ASIA D, and 5 remained stable. At the 6- and 12-week follow-up, better ASIA scores were associated with better scores on multiple SF-36v2 and SOSGOQ items. Postoperatively, patients with ASIA grades of A to D were more likely to have urinary tract infections and wound complications. Patients with a baseline ASIA grade of E or D survived significantly longer. Conclusions: Patients with neurologic deficits due to MESCC have worse HRQOL and decreased overall survival. Nevertheless, surgery can result in stabilization or improvement of neurologic function which may translate into better HRQOL. Postoperative care and follow-up are challenging for patients with neurologic deficits because they experience more complications.

KW - health-related quality of life (HRQOL)

KW - neurologic deficit

KW - spine

KW - surgery

KW - treatment

KW - tumor

UR - http://www.scopus.com/inward/record.url?scp=85070759538&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070759538&partnerID=8YFLogxK

U2 - 10.1002/cncr.32420

DO - 10.1002/cncr.32420

M3 - Article

C2 - 31410854

AN - SCOPUS:85070759538

SN - 0008-543X

VL - 125

SP - 4224

EP - 4231

JO - Cancer

JF - Cancer

IS - 23

ER -

Association of neurologic deficits with surgical outcomes and health-related quality of life after treatment for metastatic epidural spinal cord compression

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Keywords

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