Association of physical activity with self-reported quality of life after primary chemotherapy for ovarian cancer.

5574Background: Patients (pts) with advanced stage ovarian cancer may proceed to maintenance therapy or routine surveillance following primary treatment. As part of a larger research study to assess real world experiences of pts, we explored whether physical activity was associated with self-reported quality of life (QOL). Methods: Pts were asked to wear a wrist health tracker and complete the FACT-Ovarian (FACT-O) survey at baseline and every 3 months for up to 24 months. Total FACT-O score, including well-being subscales for physical (PWB), social (SWB), emotional (EWB), functional (FWB), and ovarian cancer-specific QOL were calculated. Health tracker data corresponding to each FACT-O 7-day recall period were analyzed. Multilevel linear regression analysis examined the relationship between FACT-O and 7-day health tracker data. The potential moderating effect by age (<60 vs. ≥ 60 yrs) was examined. Results: Data were analyzed for 77 pts with 250 total observations. Median age was 59 yrs (range 31, 82); 69% were White (6/53 pts self-identified as Hispanic), 4% Black, 9% Asian, 17% Other (13/14 pts self-identified as Hispanic). Of the 77 pts, 73% were married/partnered; median BMI 25.5; the majority had some college education. Pts completed a mean of 3 FACT-O surveys beyond baseline. Younger pts had better PWB (p<.01) and FWB (p<.01) than older pts, while older pts had better SWB (p<.01). Compared to older pts, younger pts had more daily activity minutes (19.9 vs 10.2, p<.01) and higher step counts (7035 vs 4689.8, p<.01). Apart from SWB and FWB with activity minutes, activity minutes and step counts were positively associated with FACT-O overall and subscale scores (Table). Older pts had stronger positive associations between physical activity minutes and PWB (p<.001), step counts and PWB (p<.001); step counts and FWB (p=.004), while younger pts had stronger positive associations between step counts and ovarian cancer-specific QOL (p=.03). Positive associations between physical activity minutes and SWB (p<.001) and EWB (p=.03), and ovarian cancer-specific QOL with activity minutes (p<.001) were observed only in younger patients. Conclusions: We observed positive associations between health tracker physical activity data and pt-reported QOL. Stronger associations were observed in younger pts. Interventions aimed at increasing physical activity may have broader quality of life benefits for individuals with ovarian cancer.