TY - JOUR
T1 - Associations between complete remission and 2- to 3-year survival following 7 + 3 induction for acute myeloid leukemia
AU - Othus, Megan
AU - Garcia-Manero, Guillermo
AU - Godwin, John
AU - Weick, James
AU - Stirewalt, Derek
AU - Appelbaum, Frederick
AU - Erba, Harry
AU - Estey, Elihu
N1 - Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021
Y1 - 2021
N2 - Among acute myeloid leukemia (AML) patients treated with 7 + 3 induction, we evaluate the association between complete morphologic remission (CR) and long-term overall survival (OS) over four decades. We analyzed 1247 patients age (Formula presented.) 65 randomized to 7 + 3 arms from five SWOG studies. OS has improved over the four decades. Hazards for death in the two most recent studies fell after year 2. In multivariable models, decade of therapy was the most important variable with respect to long-term survival and CR by day 100 the second most important variable. Protocol/decade, which captures many factors not included in our multivariable model, was the most important predictor of being alive at year 2 or 3. The next most important factor was achievement of first CR by day 100.
AB - Among acute myeloid leukemia (AML) patients treated with 7 + 3 induction, we evaluate the association between complete morphologic remission (CR) and long-term overall survival (OS) over four decades. We analyzed 1247 patients age (Formula presented.) 65 randomized to 7 + 3 arms from five SWOG studies. OS has improved over the four decades. Hazards for death in the two most recent studies fell after year 2. In multivariable models, decade of therapy was the most important variable with respect to long-term survival and CR by day 100 the second most important variable. Protocol/decade, which captures many factors not included in our multivariable model, was the most important predictor of being alive at year 2 or 3. The next most important factor was achievement of first CR by day 100.
KW - Acute myeloid leukemia
KW - complete remission
KW - induction
KW - overall survival
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U2 - 10.1080/10428194.2021.1885663
DO - 10.1080/10428194.2021.1885663
M3 - Article
C2 - 33719833
AN - SCOPUS:85102516937
SN - 1042-8194
VL - 62
SP - 1967
EP - 1972
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 8
ER -