TY - JOUR
T1 - Associations of blood mitochondrial DNA copy number with social-demographics and cancer risk
T2 - Results from the Mano-AMano Mexican American Cohort
AU - Zhao, Hua
AU - Chang, David
AU - Ye, Yuanqing
AU - Shen, Jie
AU - Chow, Wong Ho
AU - Wu, Xifeng
N1 - Funding Information:
None declared. The Cohort receives funds collected pursuant to the Comprehensive Tobacco Settlement of 1998 and appropriated by the 76th legislature to The University of Texas MD Anderson Cancer Center. This work was supported in part by Center for Translational and Public Health Genomics, the Dan Duncan Family Institute for Risk Assessment and Cancer Prevention. The funders did not contribute to the design and conduct of the study; the collection, analysis, or interpretation of the data; or the preparation, review, or approval of the manuscript.
Publisher Copyright:
© Zhao et al.
PY - 2018/5/22
Y1 - 2018/5/22
N2 - The relationship between blood mitochondrial DNA (mtDNA) copy number and subsequent cancer risk has been investigated previously. However, such association has never been examined in Mexican Americans. In the current study, we examined association between social-demographic factors and blood mtDNA copy number, as well as longitudinal relationship between cancer and mtDNA copy number, among 10,802 Mexican Americans in the Mano-A-Mano Mexican American Cohort. Overall, mtDNA copy number was statistically significantly higher among participants who developed cancer during the study period than among cancer-free controls (0.17 vs 0.13, P = 0.007). Among cancer-free control participants, mtDNA copy number significantly differed by social-demographic characteristics. However, there was a large degree of heterogeneity in these effects across the mtDNA copy number distribution. In the longitudinal analysis, we observed that higher mtDNA copy number was positively associated with increased risk of all cancer types (adjusted hazard ratio [HR], 1.13; 95% confidence interval [CI], 1.09-1.17). Participants with mtDNA copy number in the fourth (highest) quartile had a higher risk of all cancer (adjusted HR, 2.12; 95% CI, 1.65-2.73) than did participants in the first (lowest) quartile. In summary, our results in Mexican Americans support an association between increased mtDNA copy number and cancer risk. Our results also suggest that mtDNA copy number may be influenced by social and demographic factors.
AB - The relationship between blood mitochondrial DNA (mtDNA) copy number and subsequent cancer risk has been investigated previously. However, such association has never been examined in Mexican Americans. In the current study, we examined association between social-demographic factors and blood mtDNA copy number, as well as longitudinal relationship between cancer and mtDNA copy number, among 10,802 Mexican Americans in the Mano-A-Mano Mexican American Cohort. Overall, mtDNA copy number was statistically significantly higher among participants who developed cancer during the study period than among cancer-free controls (0.17 vs 0.13, P = 0.007). Among cancer-free control participants, mtDNA copy number significantly differed by social-demographic characteristics. However, there was a large degree of heterogeneity in these effects across the mtDNA copy number distribution. In the longitudinal analysis, we observed that higher mtDNA copy number was positively associated with increased risk of all cancer types (adjusted hazard ratio [HR], 1.13; 95% confidence interval [CI], 1.09-1.17). Participants with mtDNA copy number in the fourth (highest) quartile had a higher risk of all cancer (adjusted HR, 2.12; 95% CI, 1.65-2.73) than did participants in the first (lowest) quartile. In summary, our results in Mexican Americans support an association between increased mtDNA copy number and cancer risk. Our results also suggest that mtDNA copy number may be influenced by social and demographic factors.
KW - Cancer risk
KW - Lifestyle factors
KW - Mitochondrial DNA copy number
KW - Social context
UR - http://www.scopus.com/inward/record.url?scp=85047381089&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047381089&partnerID=8YFLogxK
U2 - 10.18632/oncotarget.25321
DO - 10.18632/oncotarget.25321
M3 - Article
C2 - 29876003
AN - SCOPUS:85047381089
SN - 1949-2553
VL - 9
SP - 25491
EP - 25502
JO - Oncotarget
JF - Oncotarget
IS - 39
ER -