Aurora A kinase activates YAP signaling in triple-negative breast cancer

S. S. Chang; H. Yamaguchi; W. Xia; S. O. Lim; Y. Khotskaya; Y. Wu; W. C. Chang; Q. Liu; M. C. Hung

doi:10.1038/onc.2016.292

Aurora A kinase activates YAP signaling in triple-negative breast cancer

S. S. Chang, H. Yamaguchi, W. Xia, S. O. Lim, Y. Khotskaya, Y. Wu, W. C. Chang, Q. Liu, M. C. Hung

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

The Yes-associated protein (YAP) is an effector that transduces the output of the Hippo pathway to transcriptional modulation. Considering the role of YAP in cancers, this protein has emerged as a key node in malignancy development. In this study, we determined that Aurora A kinase acts as a positive regulator for YAP-mediated transcriptional machinery. Specifically, YAP associates with Aurora A predominantly in the nucleus. Activation of Aurora A can impinge on YAP activity through direct phosphorylation. Moreover, aberrant expression of YAP and Aurora A signaling is highly correlated with triple-negative breast cancer (TNBC). We herein provide evidence to establish the functional relevance of this newly discovered regulatory axis in TNBC.

Original language	English (US)
Pages (from-to)	1265-1275
Number of pages	11
Journal	Oncogene
Volume	36
Issue number	9
DOIs	https://doi.org/10.1038/onc.2016.292
State	Published - Mar 2 2017

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

MD Anderson CCSG core facilities

Advanced Technology Genomics Core
Functional Genomics Core
Tissue Biospecimen and Pathology Resource
Cytogenetics and Cell Authentication Core
Clinical Trials Office

Access to Document

10.1038/onc.2016.292

Cite this

@article{d0eff97021004e60ab135d101f602368,

title = "Aurora A kinase activates YAP signaling in triple-negative breast cancer",

abstract = "The Yes-associated protein (YAP) is an effector that transduces the output of the Hippo pathway to transcriptional modulation. Considering the role of YAP in cancers, this protein has emerged as a key node in malignancy development. In this study, we determined that Aurora A kinase acts as a positive regulator for YAP-mediated transcriptional machinery. Specifically, YAP associates with Aurora A predominantly in the nucleus. Activation of Aurora A can impinge on YAP activity through direct phosphorylation. Moreover, aberrant expression of YAP and Aurora A signaling is highly correlated with triple-negative breast cancer (TNBC). We herein provide evidence to establish the functional relevance of this newly discovered regulatory axis in TNBC.",

author = "Chang, {S. S.} and H. Yamaguchi and W. Xia and Lim, {S. O.} and Y. Khotskaya and Y. Wu and Chang, {W. C.} and Q. Liu and Hung, {M. C.}",

note = "Funding Information: This study was funded in part by the following: National Institutes of Health grants (CA109311, CA099031 and Cancer Center Support Grant CA016672); Publisher Copyright: {\textcopyright} 2017 Macmillan Publishers Limited, part of Springer Nature.",

year = "2017",

month = mar,

day = "2",

doi = "10.1038/onc.2016.292",

language = "English (US)",

volume = "36",

pages = "1265--1275",

journal = "Oncogene",

issn = "0950-9232",

publisher = "Nature Publishing Group",

number = "9",

}

TY - JOUR

T1 - Aurora A kinase activates YAP signaling in triple-negative breast cancer

AU - Chang, S. S.

AU - Yamaguchi, H.

AU - Xia, W.

AU - Lim, S. O.

AU - Khotskaya, Y.

AU - Wu, Y.

AU - Chang, W. C.

AU - Liu, Q.

AU - Hung, M. C.

N1 - Funding Information: This study was funded in part by the following: National Institutes of Health grants (CA109311, CA099031 and Cancer Center Support Grant CA016672); Publisher Copyright: © 2017 Macmillan Publishers Limited, part of Springer Nature.

PY - 2017/3/2

Y1 - 2017/3/2

N2 - The Yes-associated protein (YAP) is an effector that transduces the output of the Hippo pathway to transcriptional modulation. Considering the role of YAP in cancers, this protein has emerged as a key node in malignancy development. In this study, we determined that Aurora A kinase acts as a positive regulator for YAP-mediated transcriptional machinery. Specifically, YAP associates with Aurora A predominantly in the nucleus. Activation of Aurora A can impinge on YAP activity through direct phosphorylation. Moreover, aberrant expression of YAP and Aurora A signaling is highly correlated with triple-negative breast cancer (TNBC). We herein provide evidence to establish the functional relevance of this newly discovered regulatory axis in TNBC.

AB - The Yes-associated protein (YAP) is an effector that transduces the output of the Hippo pathway to transcriptional modulation. Considering the role of YAP in cancers, this protein has emerged as a key node in malignancy development. In this study, we determined that Aurora A kinase acts as a positive regulator for YAP-mediated transcriptional machinery. Specifically, YAP associates with Aurora A predominantly in the nucleus. Activation of Aurora A can impinge on YAP activity through direct phosphorylation. Moreover, aberrant expression of YAP and Aurora A signaling is highly correlated with triple-negative breast cancer (TNBC). We herein provide evidence to establish the functional relevance of this newly discovered regulatory axis in TNBC.

UR - http://www.scopus.com/inward/record.url?scp=84991035953&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991035953&partnerID=8YFLogxK

U2 - 10.1038/onc.2016.292

DO - 10.1038/onc.2016.292

M3 - Article

C2 - 27593935

AN - SCOPUS:84991035953

SN - 0950-9232

VL - 36

SP - 1265

EP - 1275

JO - Oncogene

JF - Oncogene

IS - 9

ER -

Aurora A kinase activates YAP signaling in triple-negative breast cancer

Abstract

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

Other files and links

Fingerprint

Cite this