Author Correction: Ultra high dose rate (35 Gy/sec) radiation does not spare the normal tissue in cardiac and splenic models of lymphopenia and gastrointestinal syndrome (Scientific Reports, (2019), 9, 1, (17180), 10.1038/s41598-019-53562-y)

Bhanu Prasad Venkatesulu, Amrish Sharma, Julianne M. Pollard-Larkin, Ramaswamy Sadagopan, Jessica Symons, Shinya Neri, Pankaj K. Singh, Ramesh Tailor, Steven H. Lin, Sunil Krishnan

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7 Scopus citations

Abstract

In this Article, details on beam pulse structure, geometry, beam flatness and inferred instantaneous dose rate were omitted; as a result, the Materials and Methods should contain the following section: “Beam Parameters We used a pulse rate of 180Hz, pulse length of 4us, 20 MeV electrons, and a uniform dose/dose rate over a 2 × 2 cm2 or 4 × 4 cm2 field. Figure 1 below illustrates flatness and dose uniformity of these fields. The in-plane (A) and cross-plane (B) 80% widths for the 2 × 2 cm2 cut-out were both 1.8 cm whereas that for the 4 × 4 cm2 cut-out were 4.0 cm and 2.9 cm, respectively. The dose rates were calculated by dividing the dose measured using film by the gate time set for the delivery. The dose rates ranged from 66% to 115% of average dose rate of 32.6 Gy/s for the 2 × 2 cm2 field. The corresponding values for the open 4 × 4 cm2 field were 96% to 131% of the average dose rate of 38.8 Gy/s. A larger uncertainty in dose rates when delivering small doses over short gate times is likely due to a greater contribution by timer error. This initial delay or timer error of about 31 ms is estimated by the x-intercept of the calibration curve, Fig. 2 below, which plots the charge collected using an A16 ion-chamber (in nC) against gating signal width (in ms). Although the delivered dose rate was linear with time, this initial delay has a greater impact on irradiation time for smaller doses. (Figure presented.).

Original languageEnglish (US)
Article number11018
JournalScientific reports
Volume10
Issue number1
DOIs
StatePublished - Dec 1 2020

ASJC Scopus subject areas

  • General

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