AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN CALLA-POSITIVE ACUTE LYMPHOBLASTIC LEUKAEMIA AFTER IN-VITRO TREATMENT WITH J5 MONOCLONAL ANTIBODY AND COMPLEMENT

Jerome Ritz; Robert C. Bast; Luis A. Clavell; Thierry Hercend; Stephen E. Sallan; Jeffrey M. Lipton; Maryellen Feeney; David G. Nathan; Stuart F. Schlossman

doi:10.1016/S0140-6736(82)91686-5

AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN CALLA-POSITIVE ACUTE LYMPHOBLASTIC LEUKAEMIA AFTER IN-VITRO TREATMENT WITH J5 MONOCLONAL ANTIBODY AND COMPLEMENT

Jerome Ritz, Robert C. Bast, Luis A. Clavell, Thierry Hercend, Stephen E. Sallan, Jeffrey M. Lipton, Maryellen Feeney, David G. Nathan, Stuart F. Schlossman

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Abstract

A monoclonal antibody (J5) specific for the common acute-lymphoblastic-leukaemia antigen (CALLA) was used for in-vitro pre-treatment of bone-marrow before autologous transplantation in four patients with CALLA-positive acute lymphoblastic leukaemia (ALL) in relapse, who did not have HLA-compatible donors. After remission induction and intensification, bone-marrow cells were harvested, treated with J5 antibody and rabbit complement, and cryopreserved in liquid nitrogen. Patients received ablative chemotherapy and total-body irradiation before reinfusion of autologous J5-treated bone marrow. The transplantation protocol was well tolerated, and engraftment of normal myeloid cells occurred in all four patients. Two patients have continued in unmaintained remission with complete haematopoietic reconstitution for more than 1 year after autologous transplantation.

Original language	English (US)
Pages (from-to)	60-63
Number of pages	4
Journal	The Lancet
Volume	320
Issue number	8289
DOIs	https://doi.org/10.1016/S0140-6736(82)91686-5
State	Published - Jul 10 1982
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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@article{87d67209a8f94a3ba88d52fcfbb9bfdb,

title = "AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN CALLA-POSITIVE ACUTE LYMPHOBLASTIC LEUKAEMIA AFTER IN-VITRO TREATMENT WITH J5 MONOCLONAL ANTIBODY AND COMPLEMENT",

abstract = "A monoclonal antibody (J5) specific for the common acute-lymphoblastic-leukaemia antigen (CALLA) was used for in-vitro pre-treatment of bone-marrow before autologous transplantation in four patients with CALLA-positive acute lymphoblastic leukaemia (ALL) in relapse, who did not have HLA-compatible donors. After remission induction and intensification, bone-marrow cells were harvested, treated with J5 antibody and rabbit complement, and cryopreserved in liquid nitrogen. Patients received ablative chemotherapy and total-body irradiation before reinfusion of autologous J5-treated bone marrow. The transplantation protocol was well tolerated, and engraftment of normal myeloid cells occurred in all four patients. Two patients have continued in unmaintained remission with complete haematopoietic reconstitution for more than 1 year after autologous transplantation.",

author = "Jerome Ritz and Bast, {Robert C.} and Clavell, {Luis A.} and Thierry Hercend and Sallan, {Stephen E.} and Lipton, {Jeffrey M.} and Maryellen Feeney and Nathan, {David G.} and Schlossman, {Stuart F.}",

year = "1982",

month = jul,

day = "10",

doi = "10.1016/S0140-6736(82)91686-5",

language = "English (US)",

volume = "320",

pages = "60--63",

journal = "The Lancet",

issn = "0140-6736",

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number = "8289",

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T1 - AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN CALLA-POSITIVE ACUTE LYMPHOBLASTIC LEUKAEMIA AFTER IN-VITRO TREATMENT WITH J5 MONOCLONAL ANTIBODY AND COMPLEMENT

AU - Ritz, Jerome

AU - Bast, Robert C.

AU - Clavell, Luis A.

AU - Hercend, Thierry

AU - Sallan, Stephen E.

AU - Lipton, Jeffrey M.

AU - Feeney, Maryellen

AU - Nathan, David G.

AU - Schlossman, Stuart F.

PY - 1982/7/10

Y1 - 1982/7/10

N2 - A monoclonal antibody (J5) specific for the common acute-lymphoblastic-leukaemia antigen (CALLA) was used for in-vitro pre-treatment of bone-marrow before autologous transplantation in four patients with CALLA-positive acute lymphoblastic leukaemia (ALL) in relapse, who did not have HLA-compatible donors. After remission induction and intensification, bone-marrow cells were harvested, treated with J5 antibody and rabbit complement, and cryopreserved in liquid nitrogen. Patients received ablative chemotherapy and total-body irradiation before reinfusion of autologous J5-treated bone marrow. The transplantation protocol was well tolerated, and engraftment of normal myeloid cells occurred in all four patients. Two patients have continued in unmaintained remission with complete haematopoietic reconstitution for more than 1 year after autologous transplantation.

AB - A monoclonal antibody (J5) specific for the common acute-lymphoblastic-leukaemia antigen (CALLA) was used for in-vitro pre-treatment of bone-marrow before autologous transplantation in four patients with CALLA-positive acute lymphoblastic leukaemia (ALL) in relapse, who did not have HLA-compatible donors. After remission induction and intensification, bone-marrow cells were harvested, treated with J5 antibody and rabbit complement, and cryopreserved in liquid nitrogen. Patients received ablative chemotherapy and total-body irradiation before reinfusion of autologous J5-treated bone marrow. The transplantation protocol was well tolerated, and engraftment of normal myeloid cells occurred in all four patients. Two patients have continued in unmaintained remission with complete haematopoietic reconstitution for more than 1 year after autologous transplantation.

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AN - SCOPUS:0019981418

SN - 0140-6736

VL - 320

SP - 60

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JO - The Lancet

JF - The Lancet

IS - 8289

ER -

AUTOLOGOUS BONE-MARROW TRANSPLANTATION IN CALLA-POSITIVE ACUTE LYMPHOBLASTIC LEUKAEMIA AFTER IN-VITRO TREATMENT WITH J5 MONOCLONAL ANTIBODY AND COMPLEMENT

Abstract

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