Autophagy in osteosarcoma

Grace Nehme, Nancy Gordon

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

Osteosarcoma (OS) remains a difficult disease to treat. The standard chemotherapy regimen has not improved survival for the past three decades. Resistance to chemotherapy remains a challenge and constitutes a major concern to clinical investigators. Autophagy has been recognized as a survival mechanism implicated in resistance to chemotherapy. We previously demonstrated chemotherapy to induce autophagy in OS. However, whether induction of autophagy will lead to survival or death has been the focus of many laboratories. Autophagy is a very context-dependent process, and no specific biomarker has been identified to define whether the process will lead to survival or death. In the present chapter, we present some of the mechanisms involved in the process of autophagy and summarize some of the most recent work related to autophagy in OS and the challenges encountered with the use of old and new autophagy inhibitors.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages167-175
Number of pages9
DOIs
StatePublished - 2020

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1258
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Autophagy
  • Chemotherapy
  • Death
  • Osteosarcoma
  • Survival

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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