Awakening dormant haematopoietic stem cells

Andreas Trumpp, Marieke Essers, Anne Wilson

Research output: Contribution to journalComment/debate

250 Citations (Scopus)

Abstract

Haematopoietic stem cells (HSCs) in mouse bone marrow are located in specialized niches as single cells. During homeostasis, signals from this environment keep some HSCs dormant, which preserves long-term self-renewal potential, while other HSCs actively self renew to maintain haematopoiesis. In response to haematopoietic stress, dormant HSCs become activated and rapidly replenish the haematopoietic system. Interestingly, three factors granulocyte colony-stimulating factor, interferon-α and arsenic trioxide have been shown to efficiently activate dormant stem cells and thereby could break their resistance to anti-proliferative chemotherapeutics. Thus, we propose that two-step strategies could target resistant leukaemic stem cells by priming tumours with activators of dormancy followed by chemotherapy or targeted therapies.

Original languageEnglish (US)
Pages (from-to)201-209
Number of pages9
JournalNature Reviews Immunology
Volume10
Issue number3
DOIs
StatePublished - Mar 1 2010

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Hematopoietic Stem Cells
Hematopoietic System
Neoplastic Stem Cells
Hematopoiesis
Granulocyte Colony-Stimulating Factor
Interferons
Homeostasis
Stem Cells
Bone Marrow
Drug Therapy
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Awakening dormant haematopoietic stem cells. / Trumpp, Andreas; Essers, Marieke; Wilson, Anne.

In: Nature Reviews Immunology, Vol. 10, No. 3, 01.03.2010, p. 201-209.

Research output: Contribution to journalComment/debate

Trumpp, Andreas ; Essers, Marieke ; Wilson, Anne. / Awakening dormant haematopoietic stem cells. In: Nature Reviews Immunology. 2010 ; Vol. 10, No. 3. pp. 201-209.
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