Axis of ageing: Telomeres, p53 and mitochondria

Ergün Sahin, Ronald A. DePinho

Research output: Contribution to journalComment/debatepeer-review

272 Scopus citations

Abstract

Progressive DNA damage and mitochondrial decline are both considered to be prime instigators of natural ageing. Traditionally, these two pathways have been viewed largely in isolation. However, recent studies have revealed a molecular circuit that directly links DNA damage to compromised mitochondrial biogenesis and function via p53. This axis of ageing may account for both organ decline and disease development associated with advanced age and could illuminate a path for the development of relevant therapeutics.

Original languageEnglish (US)
Pages (from-to)397-404
Number of pages8
JournalNature Reviews Molecular Cell Biology
Volume13
Issue number6
DOIs
StatePublished - Jun 2012

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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