Abstract
Progressive DNA damage and mitochondrial decline are both considered to be prime instigators of natural ageing. Traditionally, these two pathways have been viewed largely in isolation. However, recent studies have revealed a molecular circuit that directly links DNA damage to compromised mitochondrial biogenesis and function via p53. This axis of ageing may account for both organ decline and disease development associated with advanced age and could illuminate a path for the development of relevant therapeutics.
Original language | English (US) |
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Pages (from-to) | 397-404 |
Number of pages | 8 |
Journal | Nature Reviews Molecular Cell Biology |
Volume | 13 |
Issue number | 6 |
DOIs |
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State | Published - Jun 2012 |
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology