B-cell lymphoma/leukaemia 11B (BCL11B) expression status helps distinguish early T-cell precursor acute lymphoblastic leukaemia/lymphoma (ETP-ALL/LBL) from other subtypes of T-cell ALL/LBL

Hong Fang; Wei Wang; Siba El Hussein; Kiyomi Morita; Hannah C. Beird; Akash Mitra; Sanam Loghavi; Pei Lin; Elias J. Jabbour; Joseph D. Khoury

doi:10.1111/bjh.17681

B-cell lymphoma/leukaemia 11B (BCL11B) expression status helps distinguish early T-cell precursor acute lymphoblastic leukaemia/lymphoma (ETP-ALL/LBL) from other subtypes of T-cell ALL/LBL

Hong Fang, Wei Wang, Siba El Hussein, Kiyomi Morita, Hannah C. Beird, Akash Mitra, Sanam Loghavi, Pei Lin, Elias J. Jabbour, Joseph D. Khoury

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

B-cell lymphoma/leukaemia 11B (BCL11B) is an essential transcription factor for T-cell lineage commitment and maturation. We investigated BCL11B expression by immunohistochemistry in T-lymphoblastic leukaemia/lymphoma (T-ALL/LBL) (n = 115). The majority (83%) of early T-cell precursor T-ALL/LBL (ETP-ALL) cases showed negative BCL11B expression, while most (84%) of non-ETP-ALL/LBL were positive for BCL11B. A simplified three-marker [BCL11B, cluster of differentiation 5 (CD5), CD13] immunophenotypic score discriminated reliably between ETP-ALL and non-ETP-ALL/LBL. In ETP-ALL, patients with positive BCL11B expression had a better overall survival than those with negative BCL11B (P = 0·009). In summary, BCL11B is a valuable marker for T-ALL/LBL subtyping and serves as a potential prognostic marker in patients with ETP-ALL.

Original language	English (US)
Pages (from-to)	1034-1038
Number of pages	5
Journal	British Journal of Haematology
Volume	194
Issue number	6
DOIs	https://doi.org/10.1111/bjh.17681
State	Published - Sep 2021

Keywords

BCL11B
T-cell differentiation
T-lymphoblastic leukaemia/lymphoma
early T-cell precursor lymphoblastic leukaemia
immunohistochemistry

ASJC Scopus subject areas

Hematology

Access to Document

10.1111/bjh.17681

Cite this

Fang, H., Wang, W., El Hussein, S., Morita, K., Beird, H. C., Mitra, A., Loghavi, S., Lin, P., Jabbour, E. J., & Khoury, J. D. (2021). B-cell lymphoma/leukaemia 11B (BCL11B) expression status helps distinguish early T-cell precursor acute lymphoblastic leukaemia/lymphoma (ETP-ALL/LBL) from other subtypes of T-cell ALL/LBL. British Journal of Haematology, 194(6), 1034-1038. https://doi.org/10.1111/bjh.17681

B-cell lymphoma/leukaemia 11B (BCL11B) expression status helps distinguish early T-cell precursor acute lymphoblastic leukaemia/lymphoma (ETP-ALL/LBL) from other subtypes of T-cell ALL/LBL. / Fang, Hong ; Wang, Wei; El Hussein, Siba et al.
In: British Journal of Haematology, Vol. 194, No. 6, 09.2021, p. 1034-1038.

Research output: Contribution to journal › Article › peer-review

Fang, H , Wang, W, El Hussein, S, Morita, K, Beird, HC, Mitra, A, Loghavi, S , Lin, P , Jabbour, EJ & Khoury, JD 2021, 'B-cell lymphoma/leukaemia 11B (BCL11B) expression status helps distinguish early T-cell precursor acute lymphoblastic leukaemia/lymphoma (ETP-ALL/LBL) from other subtypes of T-cell ALL/LBL', British Journal of Haematology, vol. 194, no. 6, pp. 1034-1038. https://doi.org/10.1111/bjh.17681

@article{bfe9f3ce0a284015bbd530e49ee97278,

title = "B-cell lymphoma/leukaemia 11B (BCL11B) expression status helps distinguish early T-cell precursor acute lymphoblastic leukaemia/lymphoma (ETP-ALL/LBL) from other subtypes of T-cell ALL/LBL",

abstract = "B-cell lymphoma/leukaemia 11B (BCL11B) is an essential transcription factor for T-cell lineage commitment and maturation. We investigated BCL11B expression by immunohistochemistry in T-lymphoblastic leukaemia/lymphoma (T-ALL/LBL) (n = 115). The majority (83%) of early T-cell precursor T-ALL/LBL (ETP-ALL) cases showed negative BCL11B expression, while most (84%) of non-ETP-ALL/LBL were positive for BCL11B. A simplified three-marker [BCL11B, cluster of differentiation 5 (CD5), CD13] immunophenotypic score discriminated reliably between ETP-ALL and non-ETP-ALL/LBL. In ETP-ALL, patients with positive BCL11B expression had a better overall survival than those with negative BCL11B (P = 0·009). In summary, BCL11B is a valuable marker for T-ALL/LBL subtyping and serves as a potential prognostic marker in patients with ETP-ALL.",

keywords = "BCL11B, T-cell differentiation, T-lymphoblastic leukaemia/lymphoma, early T-cell precursor lymphoblastic leukaemia, immunohistochemistry",

author = "Hong Fang and Wei Wang and {El Hussein}, Siba and Kiyomi Morita and Beird, {Hannah C.} and Akash Mitra and Sanam Loghavi and Pei Lin and Jabbour, {Elias J.} and Khoury, {Joseph D.}",

note = "Funding Information: Akash Mitra is supported by the Cancer Prevention and Research Institute of Texas (CPRIT) Research Training Programme (RP170067). The authors thank the staff of the immunohistochemistry laboratory at the University of Texas MD Anderson Cancer Center. Funding Information: Akash Mitra is supported by the Cancer Prevention and Research Institute of Texas (CPRIT) Research Training Programme (RP170067). Publisher Copyright: {\textcopyright} 2021 British Society for Haematology and John Wiley & Sons Ltd",

year = "2021",

month = sep,

doi = "10.1111/bjh.17681",

language = "English (US)",

volume = "194",

pages = "1034--1038",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - B-cell lymphoma/leukaemia 11B (BCL11B) expression status helps distinguish early T-cell precursor acute lymphoblastic leukaemia/lymphoma (ETP-ALL/LBL) from other subtypes of T-cell ALL/LBL

AU - Fang, Hong

AU - Wang, Wei

AU - El Hussein, Siba

AU - Morita, Kiyomi

AU - Beird, Hannah C.

AU - Mitra, Akash

AU - Loghavi, Sanam

AU - Lin, Pei

AU - Jabbour, Elias J.

AU - Khoury, Joseph D.

N1 - Funding Information: Akash Mitra is supported by the Cancer Prevention and Research Institute of Texas (CPRIT) Research Training Programme (RP170067). The authors thank the staff of the immunohistochemistry laboratory at the University of Texas MD Anderson Cancer Center. Funding Information: Akash Mitra is supported by the Cancer Prevention and Research Institute of Texas (CPRIT) Research Training Programme (RP170067). Publisher Copyright: © 2021 British Society for Haematology and John Wiley & Sons Ltd

PY - 2021/9

Y1 - 2021/9

N2 - B-cell lymphoma/leukaemia 11B (BCL11B) is an essential transcription factor for T-cell lineage commitment and maturation. We investigated BCL11B expression by immunohistochemistry in T-lymphoblastic leukaemia/lymphoma (T-ALL/LBL) (n = 115). The majority (83%) of early T-cell precursor T-ALL/LBL (ETP-ALL) cases showed negative BCL11B expression, while most (84%) of non-ETP-ALL/LBL were positive for BCL11B. A simplified three-marker [BCL11B, cluster of differentiation 5 (CD5), CD13] immunophenotypic score discriminated reliably between ETP-ALL and non-ETP-ALL/LBL. In ETP-ALL, patients with positive BCL11B expression had a better overall survival than those with negative BCL11B (P = 0·009). In summary, BCL11B is a valuable marker for T-ALL/LBL subtyping and serves as a potential prognostic marker in patients with ETP-ALL.

AB - B-cell lymphoma/leukaemia 11B (BCL11B) is an essential transcription factor for T-cell lineage commitment and maturation. We investigated BCL11B expression by immunohistochemistry in T-lymphoblastic leukaemia/lymphoma (T-ALL/LBL) (n = 115). The majority (83%) of early T-cell precursor T-ALL/LBL (ETP-ALL) cases showed negative BCL11B expression, while most (84%) of non-ETP-ALL/LBL were positive for BCL11B. A simplified three-marker [BCL11B, cluster of differentiation 5 (CD5), CD13] immunophenotypic score discriminated reliably between ETP-ALL and non-ETP-ALL/LBL. In ETP-ALL, patients with positive BCL11B expression had a better overall survival than those with negative BCL11B (P = 0·009). In summary, BCL11B is a valuable marker for T-ALL/LBL subtyping and serves as a potential prognostic marker in patients with ETP-ALL.

KW - BCL11B

KW - T-cell differentiation

KW - T-lymphoblastic leukaemia/lymphoma

KW - early T-cell precursor lymphoblastic leukaemia

KW - immunohistochemistry

UR - http://www.scopus.com/inward/record.url?scp=85112402331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85112402331&partnerID=8YFLogxK

U2 - 10.1111/bjh.17681

DO - 10.1111/bjh.17681

M3 - Article

C2 - 34402058

AN - SCOPUS:85112402331

SN - 0007-1048

VL - 194

SP - 1034

EP - 1038

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 6

ER -

B-cell lymphoma/leukaemia 11B (BCL11B) expression status helps distinguish early T-cell precursor acute lymphoblastic leukaemia/lymphoma (ETP-ALL/LBL) from other subtypes of T-cell ALL/LBL

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this