Bacterial Pneumonia in Patients with Cancer: Novel Risk Factors and Management

Justin L. Wong, Scott E. Evans

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations

Abstract

Bacterial pneumonias exact unacceptable morbidity on patients with cancer. Although the risk is often most pronounced among patients with treatment-induced cytopenias, the numerous contributors to life-threatening pneumonias in cancer populations range from derangements of lung architecture and swallow function to complex immune defects associated with cytotoxic therapies and graft-versus-host disease. These structural and immunologic abnormalities often make the diagnosis of pneumonia challenging in patients with cancer and impact the composition and duration of therapy. This article addresses host factors that contribute to pneumonia susceptibility, summarizes diagnostic recommendations, and reviews current guidelines for management of bacterial pneumonia in patients with cancer.

Original languageEnglish (US)
Pages (from-to)263-277
Number of pages15
JournalClinics in Chest Medicine
Volume38
Issue number2
DOIs
StatePublished - Jun 2017

Keywords

  • Bacterial pneumonia
  • Cancer
  • Hematologic malignancy
  • Immunocompromised host pneumonia
  • Neutropenia
  • Stem cell transplant

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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