Bai-hu-tang, ancient chinese medicine formula, may provide a new complementary treatment option for sepsis

Chien Jung Lin, Yi Chang Su, Cheng Hung Lee, Tsai Chung Li, Yun An Chen, Sunny Jui Shan Lin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Bai-Hu-Tang (BHT) has been broadly applied to treating the early stage of acute infection with systemic inflammation for two thousand years in Chinese medicine. We explore whether BHT is beneficial in treating sepsis and its effects on proinflammatory cytokine, interleukin-6, and anti-inflammatory cytokine interleukin-10, in which both play key roles in the progress of sepsis. Thirty-six male Sprague-Dawley rats were randomized into six groups, with cecal ligation and puncture (CLP) performed in all but the sham-control group. Rats in CLP + BHT-L6 and CLP + BHT-H6 groups, respectively, received a low (0.45 g/kg) and high doses (0.9 g/kg) of BHT, 6 hrs postoperatively. CLP + BHT-L12 and CLP + BHT-H12 groups, respectively, received low and high doses of BHT, 12 hrs postoperatively. Sham-control and sepsis-control groups received distilled water (1 mL) as vehicle, 6 hrs postoperatively. Serial blood samples were drawn before operation, as baseline, and at 4, 8, and 12 hrs postoperatively for IL-6 and IL-10 assay. All rats were monitored for 3 days for survival study. Rats in the CLP + BHT-H6 group had significantly higher survival rate (80%) and significantly lower levels of both IL-6 and IL-10 at 12 hrs postoperatively than those in the sepsis-control group. Results suggested that BHT may be a new complementary treatment option for sepsis.

Original languageEnglish (US)
Article number193084
JournalEvidence-based Complementary and Alternative Medicine
Volume2013
DOIs
StatePublished - Jun 12 2013

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Sepsis
Medicine
Punctures
Ligation
Interleukin-10
Therapeutics
Interleukin-6
Control Groups
L 012
bai-hu-tang
Cytokines
Sprague Dawley Rats
Anti-Inflammatory Agents
Inflammation
Water
Infection

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Bai-hu-tang, ancient chinese medicine formula, may provide a new complementary treatment option for sepsis. / Lin, Chien Jung; Su, Yi Chang; Lee, Cheng Hung; Li, Tsai Chung; Chen, Yun An; Lin, Sunny Jui Shan.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2013, 193084, 12.06.2013.

Research output: Contribution to journalArticle

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