Balancing Act during Development: Lessons from a SUMO-less SF-1

Feng Ming Lin; Edward T.H. Yeh

doi:10.1016/j.devcel.2011.07.015

Balancing Act during Development: Lessons from a SUMO-less SF-1

Feng Ming Lin, Edward T.H. Yeh

Cardiology

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

When a transcription factor is modified by small ubiquitin-like modifier (SUMO), this usually represses its transcriptional activity. In this issue of Developmental Cell, Lee et al. (2011) use a knockin mouse model to show that SUMO-less SF-1 binds and activates inappropriate targets, causing changes in cell fates and endocrine abnormalities.

Original language	English (US)
Pages (from-to)	191-192
Number of pages	2
Journal	Developmental cell
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/j.devcel.2011.07.015
State	Published - Aug 16 2011

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2011.07.015

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title = "Balancing Act during Development: Lessons from a SUMO-less SF-1",

abstract = "When a transcription factor is modified by small ubiquitin-like modifier (SUMO), this usually represses its transcriptional activity. In this issue of Developmental Cell, Lee et al. (2011) use a knockin mouse model to show that SUMO-less SF-1 binds and activates inappropriate targets, causing changes in cell fates and endocrine abnormalities.",

author = "Lin, {Feng Ming} and Yeh, {Edward T.H.}",

year = "2011",

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AU - Yeh, Edward T.H.

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AB - When a transcription factor is modified by small ubiquitin-like modifier (SUMO), this usually represses its transcriptional activity. In this issue of Developmental Cell, Lee et al. (2011) use a knockin mouse model to show that SUMO-less SF-1 binds and activates inappropriate targets, causing changes in cell fates and endocrine abnormalities.

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Balancing Act during Development: Lessons from a SUMO-less SF-1

Abstract

ASJC Scopus subject areas

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