BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression

Yilei Zhang; Li Zhuang; Boyi Gan

doi:10.1080/23723556.2018.1536845

BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression

Yilei Zhang, Li Zhuang, Boyi Gan

Experimental Radiation Oncology

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

The tumor suppressor BRCA1-associated protein 1 (BAP1) is a deubiquitinase that removes histone 2A ubiquitination. How BAP1 suppresses tumor development remains elusive. Our recent study identified the cystine transporter solute carrier family 7 member 11 (SLC7A11) as a critical BAP1 target, and showed that BAP1 promotes ferroptosis (a non-apoptotic cell death) through repressing SLC7A11 expression, resulting in tumor suppression.

Original language	English (US)
Article number	1536845
Journal	Molecular and Cellular Oncology
Volume	6
Issue number	1
DOIs	https://doi.org/10.1080/23723556.2018.1536845
State	Published - Jan 2 2019

Keywords

BAP1
H2A ubiquitination
SLC7A11
ferroptosis
metabolism
tumor suppression

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.1080/23723556.2018.1536845

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title = "BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression",

abstract = "The tumor suppressor BRCA1-associated protein 1 (BAP1) is a deubiquitinase that removes histone 2A ubiquitination. How BAP1 suppresses tumor development remains elusive. Our recent study identified the cystine transporter solute carrier family 7 member 11 (SLC7A11) as a critical BAP1 target, and showed that BAP1 promotes ferroptosis (a non-apoptotic cell death) through repressing SLC7A11 expression, resulting in tumor suppression.",

keywords = "BAP1, H2A ubiquitination, SLC7A11, ferroptosis, metabolism, tumor suppression",

author = "Yilei Zhang and Li Zhuang and Boyi Gan",

note = "Funding Information: This work was supported by the National Institutes of Health [CA181196]; Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 Taylor & Francis Group, LLC.",

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AB - The tumor suppressor BRCA1-associated protein 1 (BAP1) is a deubiquitinase that removes histone 2A ubiquitination. How BAP1 suppresses tumor development remains elusive. Our recent study identified the cystine transporter solute carrier family 7 member 11 (SLC7A11) as a critical BAP1 target, and showed that BAP1 promotes ferroptosis (a non-apoptotic cell death) through repressing SLC7A11 expression, resulting in tumor suppression.

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KW - ferroptosis

KW - metabolism

KW - tumor suppression

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BAP1 suppresses tumor development by inducing ferroptosis upon SLC7A11 repression

Abstract

Keywords

ASJC Scopus subject areas

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