TY - JOUR
T1 - Bcl6 expression specifies the T follicular helper cell program in vivo
AU - Liu, Xindong
AU - Yan, Xiaowei
AU - Zhong, Bo
AU - Nurieva, Roza I.
AU - Wang, Aibo
AU - Wang, Xiaohu
AU - Martin-Orozco, Natalia
AU - Wang, Yihong
AU - Chang, Seon Hee
AU - Esplugues, Enric
AU - Flavell, Richard A.
AU - Tian, Qiang
AU - Dong, Chen
PY - 2012/9
Y1 - 2012/9
N2 - T follicular helper cells (Tfh cells) play a pivotal role in germinal center reactions, which require B cell lymphoma 6 (Bcl6) transcription factor. To analyze their relationships with other effector T cell lineages and their stability in vivo, we developed and analyzed a new Bcl6 reporter mouse alone or together with other lineage reporter systems. Assisted with genome-wide transcriptome analysis, we show substantial plasticity of T cell differentiation in the early phase of immune response. At this stage, CXCR5 appears to be expressed in a Bcl6-independent manner. Once Bcl6 is highly expressed, Tfh cells can persist in vivo and some of them develop into memory cells. Together, our results indicate Bcl6 as a bona fide marker for Tfh polarized program.
AB - T follicular helper cells (Tfh cells) play a pivotal role in germinal center reactions, which require B cell lymphoma 6 (Bcl6) transcription factor. To analyze their relationships with other effector T cell lineages and their stability in vivo, we developed and analyzed a new Bcl6 reporter mouse alone or together with other lineage reporter systems. Assisted with genome-wide transcriptome analysis, we show substantial plasticity of T cell differentiation in the early phase of immune response. At this stage, CXCR5 appears to be expressed in a Bcl6-independent manner. Once Bcl6 is highly expressed, Tfh cells can persist in vivo and some of them develop into memory cells. Together, our results indicate Bcl6 as a bona fide marker for Tfh polarized program.
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U2 - 10.1084/jem.20120219
DO - 10.1084/jem.20120219
M3 - Article
C2 - 22987803
AN - SCOPUS:84870285173
SN - 0022-1007
VL - 209
SP - 1841
EP - 1852
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 10
ER -