TY - GEN
T1 - Beamforming Design for High-Resolution Low-Intensity Focused Ultrasound Neuromodulation
AU - Fan, Boqiang
AU - Goodman, Wayne
AU - Cho, Raymond Y.
AU - Sheth, Sameer A.
AU - Bouchard, Richard R.
AU - Aazhang, Behnaam
N1 - Funding Information:
The authors would like to thank the Robert and Janice McNair Foundation for supporting this research.
Publisher Copyright:
© 2020 IEEE.
PY - 2020/5
Y1 - 2020/5
N2 - Low-intensity focused ultrasound (LIFU) has been shown to modulate neural activity. Recent experiments suggest potential applications of LIFU stimulation for treating neuropsychiatric disorders like depression and Alzheimer's. The modulation effect is usually positively correlated with the ultrasound intensity, and there exists a minimum intensity threshold for the neuromodulation to be effective. Therefore, precise configuring of the ultrasound transducer is required to sonicate the target brain region at the desired intensity with appropriate spatial resolution. In this study, we investigate the optimization of targeting through fine temporal and spatial power delivery control of a phased array of ultrasound elements. A novel metric of the ultrasound neuromodulation resolution is proposed, and an optimization problem is formulated and solved to minimize side effects in the form of off-target region sonications. Simulation results show that our method is able to significantly improve the focusing resolution compared to the benchmark and reduce the volume experiencing possible off-target neuromodulation.
AB - Low-intensity focused ultrasound (LIFU) has been shown to modulate neural activity. Recent experiments suggest potential applications of LIFU stimulation for treating neuropsychiatric disorders like depression and Alzheimer's. The modulation effect is usually positively correlated with the ultrasound intensity, and there exists a minimum intensity threshold for the neuromodulation to be effective. Therefore, precise configuring of the ultrasound transducer is required to sonicate the target brain region at the desired intensity with appropriate spatial resolution. In this study, we investigate the optimization of targeting through fine temporal and spatial power delivery control of a phased array of ultrasound elements. A novel metric of the ultrasound neuromodulation resolution is proposed, and an optimization problem is formulated and solved to minimize side effects in the form of off-target region sonications. Simulation results show that our method is able to significantly improve the focusing resolution compared to the benchmark and reduce the volume experiencing possible off-target neuromodulation.
KW - Ultrasound neuromodulation
KW - beamforming
UR - http://www.scopus.com/inward/record.url?scp=85089221948&partnerID=8YFLogxK
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U2 - 10.1109/ICASSP40776.2020.9054234
DO - 10.1109/ICASSP40776.2020.9054234
M3 - Conference contribution
AN - SCOPUS:85089221948
T3 - ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings
SP - 906
EP - 910
BT - 2020 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2020 - Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2020 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2020
Y2 - 4 May 2020 through 8 May 2020
ER -