Best Supportive Care for Patients with Chronic Lymphocytic Leukemia: Relevance of Cancer Screening and Immunizations

Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in the Western world, predominantly affecting older individuals. Advances in targeted therapies have extended survival, shifting the clinical focus toward the management of chronic health challenges. Patients with CLL often experience immune dysfunction due to both the disease and its treatments, resulting in an increased susceptibility to infections and second primary malignancies. This review outlines evidence-based strategies for preventive care in CLL, including age-appropriate cancer screenings, routine immunizations, and lifestyle modifications. By emphasizing proactive health maintenance, this article aims to support clinicians in delivering comprehensive, long-term care for patients with CLL.