Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer

Emily J. Kay; Sara Zanivan

doi:10.1002/1878-0261.13400

Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer

Emily J. Kay
, Sara Zanivan

Research output: Contribution to journal › Comment/debate › peer-review

4 Scopus citations

Abstract

Bicarbonate transport is a pre-existing mechanism of pH regulation in pancreatic ductal cells. In a recent study, Cappellesso et al. demonstrated that pancreatic ductal adenocarcinoma metabolic rewiring creates an acidic environment, enhanced by bicarbonate import into cancer cells via SLC4A4. This acidity favours protumourigenic immunosuppression. Targeting SLC4A4 neutralises environmental pH and restores antitumour immunity, sensitising tumours to immune checkpoint blockade.

Original language	English (US)
Pages (from-to)	541-544
Number of pages	4
Journal	Molecular oncology
Volume	17
Issue number	4
DOIs	https://doi.org/10.1002/1878-0261.13400
State	Published - Apr 2023
Externally published	Yes

Keywords

T-cells
acidosis
cancer
immunotherapy
metabolism
tumour microenvironment

ASJC Scopus subject areas

Molecular Medicine
Oncology
Genetics
Cancer Research

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10.1002/1878-0261.13400

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title = "Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer",

abstract = "Bicarbonate transport is a pre-existing mechanism of pH regulation in pancreatic ductal cells. In a recent study, Cappellesso et al. demonstrated that pancreatic ductal adenocarcinoma metabolic rewiring creates an acidic environment, enhanced by bicarbonate import into cancer cells via SLC4A4. This acidity favours protumourigenic immunosuppression. Targeting SLC4A4 neutralises environmental pH and restores antitumour immunity, sensitising tumours to immune checkpoint blockade.",

keywords = "T-cells, acidosis, cancer, immunotherapy, metabolism, tumour microenvironment",

author = "Kay, \{Emily J.\} and Sara Zanivan",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Molecular Oncology published by John Wiley \& Sons Ltd on behalf of Federation of European Biochemical Societies.",

year = "2023",

month = apr,

doi = "10.1002/1878-0261.13400",

language = "English (US)",

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T1 - Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer

AU - Kay, Emily J.

AU - Zanivan, Sara

PY - 2023/4

Y1 - 2023/4

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AB - Bicarbonate transport is a pre-existing mechanism of pH regulation in pancreatic ductal cells. In a recent study, Cappellesso et al. demonstrated that pancreatic ductal adenocarcinoma metabolic rewiring creates an acidic environment, enhanced by bicarbonate import into cancer cells via SLC4A4. This acidity favours protumourigenic immunosuppression. Targeting SLC4A4 neutralises environmental pH and restores antitumour immunity, sensitising tumours to immune checkpoint blockade.

KW - T-cells

KW - acidosis

KW - cancer

KW - immunotherapy

KW - metabolism

KW - tumour microenvironment

UR - https://www.scopus.com/pages/publications/85149534369

UR - https://www.scopus.com/pages/publications/85149534369#tab=citedBy

U2 - 10.1002/1878-0261.13400

DO - 10.1002/1878-0261.13400

M3 - Comment/debate

C2 - 36807529

AN - SCOPUS:85149534369

SN - 1574-7891

VL - 17

SP - 541

EP - 544

JO - Molecular oncology

JF - Molecular oncology

IS - 4

ER -

Bicarbonate transport as regulator of antitumour immunity in pancreatic cancer

Abstract

Keywords

ASJC Scopus subject areas

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