Bioactive flavone fisetin attenuates hypertension associated cardiac hypertrophy in H9c2 cells and in spontaneously hypertension rats

Kuan Ho Lin, Marthandam Asokan Shibu, Rajendran Peramaiyan, Ya Fang Chen, Chia Yao Shen, You Liang Hsieh, Ray Jade Chen, Vijaya Padma Viswanadha, Wei Wen Kuo, Chih-Yang Huang

Research output: Contribution to journalArticle

Abstract

Fisetin, a naturally occurring flavonoid in fruits, nuts and vegetables possess antioxidant and anti-inflammatory properties. This study shows that fisetin exerts preventive and therapeutic effects on hypertension associated cardiac abnormalities in H9c2 cells and Spontaneously Hypertensive Rats (SHRs). For In vitro analysis, H9c2 cells were challenged with AngII and Fisetin (50 µM/mL) was administered either before 2 h or after 12 h of AngII challenge. For In vivo studies, SHRs received oral fisetin (10 mg/kg, twice a week for 6 weeks) and their cardiac function was analyzed by echocardiography. Histological studies and Western blotting were performed to assess the severity and the mechanism of the underlying cardiac abnormality. Fisetin effectively suppressed calcineurin-NFATC3 involved cellular hypertrophic effects as observed in H9c2 cells and in SHR hearts. Fisetin also enhanced cardiac function and restored cardiac morphology and therefore, fisetin is a potential agent against hypertension associated hypertrophy and cardiac deterioration.

Original languageEnglish (US)
Pages (from-to)212-218
Number of pages7
JournalJournal of Functional Foods
Volume52
DOIs
StatePublished - Jan 1 2019

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flavone
Cardiomegaly
flavones
hypertrophy
hypertension
cardiac output
Hypertension
rats
Inbred SHR Rats
echocardiography
cells
in vivo studies
anti-inflammatory activity
nuts
mouth
Western blotting
flavonoids
vegetables
deterioration
heart

Keywords

  • 3,3′,4′,7-Tetrahydroxyflavone
  • Cardiac remodeling
  • Fisetin
  • Flavonoid
  • Hypertension

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Bioactive flavone fisetin attenuates hypertension associated cardiac hypertrophy in H9c2 cells and in spontaneously hypertension rats. / Lin, Kuan Ho; Shibu, Marthandam Asokan; Peramaiyan, Rajendran; Chen, Ya Fang; Shen, Chia Yao; Hsieh, You Liang; Chen, Ray Jade; Viswanadha, Vijaya Padma; Kuo, Wei Wen; Huang, Chih-Yang.

In: Journal of Functional Foods, Vol. 52, 01.01.2019, p. 212-218.

Research output: Contribution to journalArticle

Lin, Kuan Ho ; Shibu, Marthandam Asokan ; Peramaiyan, Rajendran ; Chen, Ya Fang ; Shen, Chia Yao ; Hsieh, You Liang ; Chen, Ray Jade ; Viswanadha, Vijaya Padma ; Kuo, Wei Wen ; Huang, Chih-Yang. / Bioactive flavone fisetin attenuates hypertension associated cardiac hypertrophy in H9c2 cells and in spontaneously hypertension rats. In: Journal of Functional Foods. 2019 ; Vol. 52. pp. 212-218.
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AU - Huang, Chih-Yang

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