Bioactive secondary metabolites from the mangrove endophytic fungi Nigrospora oryzae

Antonius Rolling Basa Ola; Titus Lapailaka; Hermania Em Wogo; Julinda Bendalina Dengga Henuk; Agnes Simamora; Lince Mukkun; Peter Proksch; Chong Dat Pham

doi:10.22146/ijc.63129

Bioactive secondary metabolites from the mangrove endophytic fungi Nigrospora oryzae

Antonius Rolling Basa Ola, Titus Lapailaka, Hermania Em Wogo, Julinda Bendalina Dengga Henuk, Agnes Simamora, Lince Mukkun, Peter Proksch, Chong Dat Pham

Cancer Systems Imaging

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Mangrove forest has a distinctive habitat adapting with marine and terrestrial environment. Chemical investigation of the extract from mangrove endophytic fungi Nigrospora oryzae had resulted in the isolation of sterigmatocystin (1) and pestalopyrone (2). The structure of sterigmatocystin (1) and pestalopyrone (2) were elucidated using mass, UV and NMR spectrometers together with the comparison with the literature data. The study also showed that sterigmatocystin displayed moderate cytotoxicity but it could be further developed as antiviral and antibacterial agent based on the SAR information reported from its analogue and derivatives.

Original language	English (US)
Pages (from-to)	1016-1022
Number of pages	7
Journal	Indonesian Journal of Chemistry
Volume	21
Issue number	4
DOIs	https://doi.org/10.22146/ijc.63129
State	Published - Apr 1 2021

Keywords

Mangrove
Nigrospora oryzae
Pestalopyrone
Sterigmatocystin

ASJC Scopus subject areas

General Chemistry

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10.22146/ijc.63129

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title = "Bioactive secondary metabolites from the mangrove endophytic fungi Nigrospora oryzae",

abstract = "Mangrove forest has a distinctive habitat adapting with marine and terrestrial environment. Chemical investigation of the extract from mangrove endophytic fungi Nigrospora oryzae had resulted in the isolation of sterigmatocystin (1) and pestalopyrone (2). The structure of sterigmatocystin (1) and pestalopyrone (2) were elucidated using mass, UV and NMR spectrometers together with the comparison with the literature data. The study also showed that sterigmatocystin displayed moderate cytotoxicity but it could be further developed as antiviral and antibacterial agent based on the SAR information reported from its analogue and derivatives.",

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T1 - Bioactive secondary metabolites from the mangrove endophytic fungi Nigrospora oryzae

AU - Ola, Antonius Rolling Basa

AU - Lapailaka, Titus

AU - Wogo, Hermania Em

AU - Henuk, Julinda Bendalina Dengga

AU - Simamora, Agnes

AU - Mukkun, Lince

AU - Proksch, Peter

AU - Pham, Chong Dat

PY - 2021/4/1

Y1 - 2021/4/1

N2 - Mangrove forest has a distinctive habitat adapting with marine and terrestrial environment. Chemical investigation of the extract from mangrove endophytic fungi Nigrospora oryzae had resulted in the isolation of sterigmatocystin (1) and pestalopyrone (2). The structure of sterigmatocystin (1) and pestalopyrone (2) were elucidated using mass, UV and NMR spectrometers together with the comparison with the literature data. The study also showed that sterigmatocystin displayed moderate cytotoxicity but it could be further developed as antiviral and antibacterial agent based on the SAR information reported from its analogue and derivatives.

AB - Mangrove forest has a distinctive habitat adapting with marine and terrestrial environment. Chemical investigation of the extract from mangrove endophytic fungi Nigrospora oryzae had resulted in the isolation of sterigmatocystin (1) and pestalopyrone (2). The structure of sterigmatocystin (1) and pestalopyrone (2) were elucidated using mass, UV and NMR spectrometers together with the comparison with the literature data. The study also showed that sterigmatocystin displayed moderate cytotoxicity but it could be further developed as antiviral and antibacterial agent based on the SAR information reported from its analogue and derivatives.

KW - Mangrove

KW - Nigrospora oryzae

KW - Pestalopyrone

KW - Sterigmatocystin

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Bioactive secondary metabolites from the mangrove endophytic fungi Nigrospora oryzae

Abstract

Keywords

ASJC Scopus subject areas

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