Biobehavioral Influences on Cancer Progression

Erin S. Costanzo; Anil K. Sood; Susan K. Lutgendorf

doi:10.1016/j.iac.2010.09.001

Biobehavioral Influences on Cancer Progression

Erin S. Costanzo, Anil K. Sood, Susan K. Lutgendorf

Research output: Contribution to journal › Review article › peer-review

97 Scopus citations

Abstract

This review focuses on the contributions of stress-related behavioral factors to cancer growth and metastasis and the biobehavioral mechanisms underlying these relationships. Behavioral factors that are important in modulation of the stress response and the pivotal role of neuroendocrine regulation in the downstream alteration of physiologic pathways relevant to cancer control, including the cellular immune response, inflammation, and tumor angiogenesis, invasion, and cell signaling pathways are described. Consequences for cancer progression and metastasis, as well as quality of life, are delineated. Behavioral and pharmacologic interventions with the potential to alter these biobehavioral pathways for patients with cancer are discussed.

Original language	English (US)
Pages (from-to)	109-132
Number of pages	24
Journal	Immunology and Allergy Clinics of North America
Volume	31
Issue number	1
DOIs	https://doi.org/10.1016/j.iac.2010.09.001
State	Published - Feb 2011
Externally published	Yes

Keywords

Angiogenesis
Cancer
Depression
Immunity
Inflammation
Stress

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.iac.2010.09.001

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title = "Biobehavioral Influences on Cancer Progression",

abstract = "This review focuses on the contributions of stress-related behavioral factors to cancer growth and metastasis and the biobehavioral mechanisms underlying these relationships. Behavioral factors that are important in modulation of the stress response and the pivotal role of neuroendocrine regulation in the downstream alteration of physiologic pathways relevant to cancer control, including the cellular immune response, inflammation, and tumor angiogenesis, invasion, and cell signaling pathways are described. Consequences for cancer progression and metastasis, as well as quality of life, are delineated. Behavioral and pharmacologic interventions with the potential to alter these biobehavioral pathways for patients with cancer are discussed.",

keywords = "Angiogenesis, Cancer, Depression, Immunity, Inflammation, Stress",

author = "Costanzo, {Erin S.} and Sood, {Anil K.} and Lutgendorf, {Susan K.}",

note = "Funding Information: This work was supported by grants KL2 RR0205012 from the Clinical and Translational Science Award (CTSA) program of the National Center for Research Resources and R21 CA133343 from the National Cancer Institute to ESC , R01 CA140933 and R01 CA104825 from the National Cancer Institute to SKL , and R01 CA110793, RO1 CA109298 , and P50 CA083693 (MD Anderson Cancer Center SPORE in Ovarian Cancer) from the National Cancer Institute and a Program Project Development Grant from the Ovarian Cancer Research Fund, Inc to AKS. ",

year = "2011",

month = feb,

doi = "10.1016/j.iac.2010.09.001",

language = "English (US)",

volume = "31",

pages = "109--132",

journal = "Immunology and Allergy Clinics of North America",

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AU - Costanzo, Erin S.

AU - Sood, Anil K.

AU - Lutgendorf, Susan K.

N1 - Funding Information: This work was supported by grants KL2 RR0205012 from the Clinical and Translational Science Award (CTSA) program of the National Center for Research Resources and R21 CA133343 from the National Cancer Institute to ESC , R01 CA140933 and R01 CA104825 from the National Cancer Institute to SKL , and R01 CA110793, RO1 CA109298 , and P50 CA083693 (MD Anderson Cancer Center SPORE in Ovarian Cancer) from the National Cancer Institute and a Program Project Development Grant from the Ovarian Cancer Research Fund, Inc to AKS.

PY - 2011/2

Y1 - 2011/2

N2 - This review focuses on the contributions of stress-related behavioral factors to cancer growth and metastasis and the biobehavioral mechanisms underlying these relationships. Behavioral factors that are important in modulation of the stress response and the pivotal role of neuroendocrine regulation in the downstream alteration of physiologic pathways relevant to cancer control, including the cellular immune response, inflammation, and tumor angiogenesis, invasion, and cell signaling pathways are described. Consequences for cancer progression and metastasis, as well as quality of life, are delineated. Behavioral and pharmacologic interventions with the potential to alter these biobehavioral pathways for patients with cancer are discussed.

AB - This review focuses on the contributions of stress-related behavioral factors to cancer growth and metastasis and the biobehavioral mechanisms underlying these relationships. Behavioral factors that are important in modulation of the stress response and the pivotal role of neuroendocrine regulation in the downstream alteration of physiologic pathways relevant to cancer control, including the cellular immune response, inflammation, and tumor angiogenesis, invasion, and cell signaling pathways are described. Consequences for cancer progression and metastasis, as well as quality of life, are delineated. Behavioral and pharmacologic interventions with the potential to alter these biobehavioral pathways for patients with cancer are discussed.

KW - Angiogenesis

KW - Cancer

KW - Depression

KW - Immunity

KW - Inflammation

KW - Stress

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DO - 10.1016/j.iac.2010.09.001

M3 - Review article

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AN - SCOPUS:78649352268

SN - 0889-8561

VL - 31

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JO - Immunology and Allergy Clinics of North America

JF - Immunology and Allergy Clinics of North America

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ER -

Biobehavioral Influences on Cancer Progression

Abstract

Keywords

ASJC Scopus subject areas

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