Biological aspects of human plasmacytoid dendritic cells and their leukemic counterparts; similarities and differences

Laura Bover; Mar Naranjo-Gómez; Shino Hanabuchi; Begoña Pérez-Cabezas; Francesc E. Borràs

doi:10.1016/S0213-9626(10)70004-4

Biological aspects of human plasmacytoid dendritic cells and their leukemic counterparts; similarities and differences

Laura Bover, Mar Naranjo-Gómez, Shino Hanabuchi, Begoña Pérez-Cabezas, Francesc E. Borràs

Genomic Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Plasmacytoid dendritic cells (pDC) are also known as natural type-I-interferon-producing cell (IPC) owing its name to an outstanding capacity to secrete large amounts of type I interferons (IFN) upon viral infections, thus constituting important mediators in antiviral immunity. This review aims to summarize some of the human pDC attributes, such as their origin, migration, as well as recent findings on interaction of pDC with other cells within the immune system. In addition, we will review the differences and similarities between pDC and their leukemic counterparts (LpDC), with a special focus on the validity of using cell lines derived from leukemic pDC as a model to study normal pDC.

Original language	English (US)
Pages (from-to)	125-134
Number of pages	10
Journal	Inmunologia
Volume	29
Issue number	4
DOIs	https://doi.org/10.1016/S0213-9626(10)70004-4
State	Published - 2010

Keywords

Leukemia
Plasmacytoid dendritic cells
Type I interferon

ASJC Scopus subject areas

Immunology

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10.1016/S0213-9626(10)70004-4

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title = "Biological aspects of human plasmacytoid dendritic cells and their leukemic counterparts; similarities and differences",

abstract = "Plasmacytoid dendritic cells (pDC) are also known as natural type-I-interferon-producing cell (IPC) owing its name to an outstanding capacity to secrete large amounts of type I interferons (IFN) upon viral infections, thus constituting important mediators in antiviral immunity. This review aims to summarize some of the human pDC attributes, such as their origin, migration, as well as recent findings on interaction of pDC with other cells within the immune system. In addition, we will review the differences and similarities between pDC and their leukemic counterparts (LpDC), with a special focus on the validity of using cell lines derived from leukemic pDC as a model to study normal pDC.",

keywords = "Leukemia, Plasmacytoid dendritic cells, Type I interferon",

author = "Laura Bover and Mar Naranjo-G{\'o}mez and Shino Hanabuchi and Bego{\~n}a P{\'e}rez-Cabezas and Borr{\`a}s, {Francesc E.}",

note = "Funding Information: F.E.B.'s group is supported by grants (FIS 06/0453 and 09/0229) from the Instituto Carlos III (ISCIII) of the Spanish Ministry of Science and Innovation (MCIN). MNG is supported by a contract {"}Torres Quevedo{"} (PTQ 09/02-01750) from the MCIN. BPC is supported by a grant (FI 07/00054) from the ISCIII. ",

year = "2010",

doi = "10.1016/S0213-9626(10)70004-4",

language = "English (US)",

volume = "29",

pages = "125--134",

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TY - JOUR

T1 - Biological aspects of human plasmacytoid dendritic cells and their leukemic counterparts; similarities and differences

AU - Bover, Laura

AU - Naranjo-Gómez, Mar

AU - Hanabuchi, Shino

AU - Pérez-Cabezas, Begoña

AU - Borràs, Francesc E.

N1 - Funding Information: F.E.B.'s group is supported by grants (FIS 06/0453 and 09/0229) from the Instituto Carlos III (ISCIII) of the Spanish Ministry of Science and Innovation (MCIN). MNG is supported by a contract "Torres Quevedo" (PTQ 09/02-01750) from the MCIN. BPC is supported by a grant (FI 07/00054) from the ISCIII.

PY - 2010

Y1 - 2010

N2 - Plasmacytoid dendritic cells (pDC) are also known as natural type-I-interferon-producing cell (IPC) owing its name to an outstanding capacity to secrete large amounts of type I interferons (IFN) upon viral infections, thus constituting important mediators in antiviral immunity. This review aims to summarize some of the human pDC attributes, such as their origin, migration, as well as recent findings on interaction of pDC with other cells within the immune system. In addition, we will review the differences and similarities between pDC and their leukemic counterparts (LpDC), with a special focus on the validity of using cell lines derived from leukemic pDC as a model to study normal pDC.

AB - Plasmacytoid dendritic cells (pDC) are also known as natural type-I-interferon-producing cell (IPC) owing its name to an outstanding capacity to secrete large amounts of type I interferons (IFN) upon viral infections, thus constituting important mediators in antiviral immunity. This review aims to summarize some of the human pDC attributes, such as their origin, migration, as well as recent findings on interaction of pDC with other cells within the immune system. In addition, we will review the differences and similarities between pDC and their leukemic counterparts (LpDC), with a special focus on the validity of using cell lines derived from leukemic pDC as a model to study normal pDC.

KW - Leukemia

KW - Plasmacytoid dendritic cells

KW - Type I interferon

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DO - 10.1016/S0213-9626(10)70004-4

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SN - 0213-9626

VL - 29

SP - 125

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JO - Inmunologia

JF - Inmunologia

IS - 4

ER -

Biological aspects of human plasmacytoid dendritic cells and their leukemic counterparts; similarities and differences

Abstract

Keywords

ASJC Scopus subject areas

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