Biological properties of extracellular vesicles and their physiological functions

María Yáñez-Mó, Pia R.M. Siljander, Zoraida Andreu, Apolonija Bedina Zavec, Francesc E. Borràs, Edit I. Buzas, Krisztina Buzas, Enriqueta Casal, Francesco Cappello, Joana Carvalho, Eva Colás, Anabela Cordeiro-Da Silva, Stefano Fais, Juan M. Falcon-Perez, Irene M. Ghobrial, Bernd Giebel, Mario Gimona, Michael Graner, Ihsan Gursel, Mayda GurselNiels H.H. Heegaard, An Hendrix, Peter Kierulf, Katsutoshi Kokubun, Maja Kosanovic, Veronika Kralj-Iglic, Eva Maria Krämer-Albers, Saara Laitinen, Cecilia Lässer, Thomas Lener, Erzsébet Ligeti, Aija Line, Georg Lipps, Alicia Llorente, Jan Lötvall, Mateja Manček-Keber, Antonio Marcilla, Maria Mittelbrunn, Irina Nazarenko, Esther N.M. Nolte-'t Hoen, Tuula A. Nyman, Lorraine O'Driscoll, Mireia Olivan, Carla Oliveira, Éva Pállinger, Hernando A. Del Portillo, Jaume Reventós, Marina Rigau, Eva Rohde, Marei Sammar, Francisco Sánchez-Madrid, N. Santarém, Katharina Schallmoser, Marie Stampe Ostenfeld, Willem Stoorvogel, Roman Stukelj, Susanne G. Van Der Grein, M. Helena Vasconcelos, Marca H.M. Wauben, Olivier De Wever

Research output: Contribution to journalReview article

1100 Citations (Scopus)

Abstract

In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells.While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.

Original languageEnglish (US)
Pages (from-to)1-60
Number of pages60
JournalJournal of Extracellular Vesicles
Volume4
Issue number2015
DOIs
StatePublished - Jan 1 2015

Fingerprint

Eukaryota
Crowdsourcing
Extracellular Vesicles
Body Fluids
Pathologic Processes
Nucleic Acids
Autoimmune Diseases
Industry
Homeostasis
Maintenance
Research Personnel
Bacteria
Neoplasms
lipid transfer protein

Keywords

  • Eukaryote
  • Exosome
  • Extracellular vesicle
  • Microparticle
  • Microvesicle
  • Physiology
  • Prokaryote

ASJC Scopus subject areas

  • Histology
  • Cell Biology

Cite this

Yáñez-Mó, M., Siljander, P. R. M., Andreu, Z., Zavec, A. B., Borràs, F. E., Buzas, E. I., ... De Wever, O. (2015). Biological properties of extracellular vesicles and their physiological functions. Journal of Extracellular Vesicles, 4(2015), 1-60. https://doi.org/10.3402/jev.v4.27066

Biological properties of extracellular vesicles and their physiological functions. / Yáñez-Mó, María; Siljander, Pia R.M.; Andreu, Zoraida; Zavec, Apolonija Bedina; Borràs, Francesc E.; Buzas, Edit I.; Buzas, Krisztina; Casal, Enriqueta; Cappello, Francesco; Carvalho, Joana; Colás, Eva; Cordeiro-Da Silva, Anabela; Fais, Stefano; Falcon-Perez, Juan M.; Ghobrial, Irene M.; Giebel, Bernd; Gimona, Mario; Graner, Michael; Gursel, Ihsan; Gursel, Mayda; Heegaard, Niels H.H.; Hendrix, An; Kierulf, Peter; Kokubun, Katsutoshi; Kosanovic, Maja; Kralj-Iglic, Veronika; Krämer-Albers, Eva Maria; Laitinen, Saara; Lässer, Cecilia; Lener, Thomas; Ligeti, Erzsébet; Line, Aija; Lipps, Georg; Llorente, Alicia; Lötvall, Jan; Manček-Keber, Mateja; Marcilla, Antonio; Mittelbrunn, Maria; Nazarenko, Irina; Nolte-'t Hoen, Esther N.M.; Nyman, Tuula A.; O'Driscoll, Lorraine; Olivan, Mireia; Oliveira, Carla; Pállinger, Éva; Del Portillo, Hernando A.; Reventós, Jaume; Rigau, Marina; Rohde, Eva; Sammar, Marei; Sánchez-Madrid, Francisco; Santarém, N.; Schallmoser, Katharina; Ostenfeld, Marie Stampe; Stoorvogel, Willem; Stukelj, Roman; Van Der Grein, Susanne G.; Helena Vasconcelos, M.; Wauben, Marca H.M.; De Wever, Olivier.

In: Journal of Extracellular Vesicles, Vol. 4, No. 2015, 01.01.2015, p. 1-60.

Research output: Contribution to journalReview article

Yáñez-Mó, M, Siljander, PRM, Andreu, Z, Zavec, AB, Borràs, FE, Buzas, EI, Buzas, K, Casal, E, Cappello, F, Carvalho, J, Colás, E, Cordeiro-Da Silva, A, Fais, S, Falcon-Perez, JM, Ghobrial, IM, Giebel, B, Gimona, M, Graner, M, Gursel, I, Gursel, M, Heegaard, NHH, Hendrix, A, Kierulf, P, Kokubun, K, Kosanovic, M, Kralj-Iglic, V, Krämer-Albers, EM, Laitinen, S, Lässer, C, Lener, T, Ligeti, E, Line, A, Lipps, G, Llorente, A, Lötvall, J, Manček-Keber, M, Marcilla, A, Mittelbrunn, M, Nazarenko, I, Nolte-'t Hoen, ENM, Nyman, TA, O'Driscoll, L, Olivan, M, Oliveira, C, Pállinger, É, Del Portillo, HA, Reventós, J, Rigau, M, Rohde, E, Sammar, M, Sánchez-Madrid, F, Santarém, N, Schallmoser, K, Ostenfeld, MS, Stoorvogel, W, Stukelj, R, Van Der Grein, SG, Helena Vasconcelos, M, Wauben, MHM & De Wever, O 2015, 'Biological properties of extracellular vesicles and their physiological functions', Journal of Extracellular Vesicles, vol. 4, no. 2015, pp. 1-60. https://doi.org/10.3402/jev.v4.27066
Yáñez-Mó M, Siljander PRM, Andreu Z, Zavec AB, Borràs FE, Buzas EI et al. Biological properties of extracellular vesicles and their physiological functions. Journal of Extracellular Vesicles. 2015 Jan 1;4(2015):1-60. https://doi.org/10.3402/jev.v4.27066
Yáñez-Mó, María ; Siljander, Pia R.M. ; Andreu, Zoraida ; Zavec, Apolonija Bedina ; Borràs, Francesc E. ; Buzas, Edit I. ; Buzas, Krisztina ; Casal, Enriqueta ; Cappello, Francesco ; Carvalho, Joana ; Colás, Eva ; Cordeiro-Da Silva, Anabela ; Fais, Stefano ; Falcon-Perez, Juan M. ; Ghobrial, Irene M. ; Giebel, Bernd ; Gimona, Mario ; Graner, Michael ; Gursel, Ihsan ; Gursel, Mayda ; Heegaard, Niels H.H. ; Hendrix, An ; Kierulf, Peter ; Kokubun, Katsutoshi ; Kosanovic, Maja ; Kralj-Iglic, Veronika ; Krämer-Albers, Eva Maria ; Laitinen, Saara ; Lässer, Cecilia ; Lener, Thomas ; Ligeti, Erzsébet ; Line, Aija ; Lipps, Georg ; Llorente, Alicia ; Lötvall, Jan ; Manček-Keber, Mateja ; Marcilla, Antonio ; Mittelbrunn, Maria ; Nazarenko, Irina ; Nolte-'t Hoen, Esther N.M. ; Nyman, Tuula A. ; O'Driscoll, Lorraine ; Olivan, Mireia ; Oliveira, Carla ; Pállinger, Éva ; Del Portillo, Hernando A. ; Reventós, Jaume ; Rigau, Marina ; Rohde, Eva ; Sammar, Marei ; Sánchez-Madrid, Francisco ; Santarém, N. ; Schallmoser, Katharina ; Ostenfeld, Marie Stampe ; Stoorvogel, Willem ; Stukelj, Roman ; Van Der Grein, Susanne G. ; Helena Vasconcelos, M. ; Wauben, Marca H.M. ; De Wever, Olivier. / Biological properties of extracellular vesicles and their physiological functions. In: Journal of Extracellular Vesicles. 2015 ; Vol. 4, No. 2015. pp. 1-60.
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