Biology and therapeutic potential of mesenchymal stem cell-derived exosomes

Zhou Xunian, Raghu Kalluri

Research output: Contribution to journalReview articlepeer-review

127 Scopus citations

Abstract

Mesenchymal stem cells (MSC) are multipotent stromal cells with the potential to differentiate into several cell types. MSC-based therapy has emerged as a promising strategy for various diseases. Accumulating evidence suggests that the paracrine effects of MSC are partially exerted by the secretion of soluble factors, in particular exosomes. MSC-derived exosomes are involved in intercellular communication through transfer of proteins, RNA, DNA and bioactive lipids, which might constitute a novel intercellular communication mode. This review illustrates the current knowledge on the composition and biological functions as well as the therapeutic potential of MSC-derived exosomes in cancer, with a focus on clinical translation opportunities.

Original languageEnglish (US)
Pages (from-to)3100-3110
Number of pages11
JournalCancer science
Volume111
Issue number9
DOIs
StatePublished - Sep 1 2020

Keywords

  • MSC-derived exosomes
  • cancer
  • exosomes
  • immunomodulation
  • mesenchymal stem cells

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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