Abstract
Mesenchymal stem cells (MSC) are multipotent stromal cells with the potential to differentiate into several cell types. MSC-based therapy has emerged as a promising strategy for various diseases. Accumulating evidence suggests that the paracrine effects of MSC are partially exerted by the secretion of soluble factors, in particular exosomes. MSC-derived exosomes are involved in intercellular communication through transfer of proteins, RNA, DNA and bioactive lipids, which might constitute a novel intercellular communication mode. This review illustrates the current knowledge on the composition and biological functions as well as the therapeutic potential of MSC-derived exosomes in cancer, with a focus on clinical translation opportunities.
Original language | English (US) |
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Pages (from-to) | 3100-3110 |
Number of pages | 11 |
Journal | Cancer science |
Volume | 111 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1 2020 |
Keywords
- MSC-derived exosomes
- cancer
- exosomes
- immunomodulation
- mesenchymal stem cells
ASJC Scopus subject areas
- Oncology
- Cancer Research