TY - JOUR
T1 - Biomarkers and imaging of breast cancer
AU - Weaver, Olena
AU - Leung, Jessica W.T.
N1 - Publisher Copyright:
© American Roentgen Ray Society.
PY - 2018/2
Y1 - 2018/2
N2 - OBJECTIVE. The goals of this review are to provide background information on the definitions and applications of the general term "biomarker" and to highlight the specifc roles of breast imaging biomarkers in research and clinical breast cancer care. A search was conducted of the main electronic biomedical databases (PubMed, Cochrane, Embase, MEDLINE [Ovid], Scopus, and Web of Science). The search was focused on review literature in general radiology and biomedical sciences and on reviews and primary research articles on biomarkers in breast imaging over the 15 years ending in June 2017. The keywords included "biomarker," "trial endpoints," "breast imaging," "breast cancer," "radiomics," and "precision medicine" in the titles and abstracts of the papers. CONCLUSION. Clinical breast care and breast cancer-related research rely on imaging biomarkers for decision support. In the era of precision medicine and big data, the practice of radiology is likely to change. A closer integration of breast imaging with related biomedical felds and the creation of large integrated and shareable databases of clinical, molecular, and imaging biomarkers should allow the feld to continue guiding breast cancer care and research.
AB - OBJECTIVE. The goals of this review are to provide background information on the definitions and applications of the general term "biomarker" and to highlight the specifc roles of breast imaging biomarkers in research and clinical breast cancer care. A search was conducted of the main electronic biomedical databases (PubMed, Cochrane, Embase, MEDLINE [Ovid], Scopus, and Web of Science). The search was focused on review literature in general radiology and biomedical sciences and on reviews and primary research articles on biomarkers in breast imaging over the 15 years ending in June 2017. The keywords included "biomarker," "trial endpoints," "breast imaging," "breast cancer," "radiomics," and "precision medicine" in the titles and abstracts of the papers. CONCLUSION. Clinical breast care and breast cancer-related research rely on imaging biomarkers for decision support. In the era of precision medicine and big data, the practice of radiology is likely to change. A closer integration of breast imaging with related biomedical felds and the creation of large integrated and shareable databases of clinical, molecular, and imaging biomarkers should allow the feld to continue guiding breast cancer care and research.
KW - Biomarkers
KW - Breast cancer
KW - Precision medicine
KW - Radiomics
KW - Trial endpoints
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U2 - 10.2214/AJR.17.18708
DO - 10.2214/AJR.17.18708
M3 - Review article
C2 - 29166151
AN - SCOPUS:85041355621
SN - 0361-803X
VL - 210
SP - 271
EP - 278
JO - American Journal of Roentgenology
JF - American Journal of Roentgenology
IS - 2
ER -