Blockade of the PD-1 pathway enhances the efficacy of adoptive cell therapy against cancer

Weiyi Peng; Gregory Lizée; Patrick Hwu

doi:10.4161/onci.22691

Blockade of the PD-1 pathway enhances the efficacy of adoptive cell therapy against cancer

Weiyi Peng, Gregory Lizée, Patrick Hwu

Melanoma Medical Oncology

Research output: Contribution to journal › Comment/debate › peer-review

33 Scopus citations

Abstract

The blockade of the PD-1 pathway can increase the production of interferon? by tumor-specific T cells located within or in the proximity of the malignant lesion, thereby increasing the chemokine-dependent trafficking of immune effector cells. This can boost the efficacy of adoptive T-cell therapy to achieve superior antitumor responses.

Original language	English (US)
Article number	e22691
Journal	OncoImmunology
Volume	2
Issue number	2
DOIs	https://doi.org/10.4161/onci.22691
State	Published - Feb 2013

Keywords

Adoptive cell therapy
Cancer immunotherapy
Checkpoint blockade
Melanoma
PD-1
PD-L1

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/onci.22691

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title = "Blockade of the PD-1 pathway enhances the efficacy of adoptive cell therapy against cancer",

abstract = "The blockade of the PD-1 pathway can increase the production of interferon? by tumor-specific T cells located within or in the proximity of the malignant lesion, thereby increasing the chemokine-dependent trafficking of immune effector cells. This can boost the efficacy of adoptive T-cell therapy to achieve superior antitumor responses.",

keywords = "Adoptive cell therapy, Cancer immunotherapy, Checkpoint blockade, Melanoma, PD-1, PD-L1",

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AU - Hwu, Patrick

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AB - The blockade of the PD-1 pathway can increase the production of interferon? by tumor-specific T cells located within or in the proximity of the malignant lesion, thereby increasing the chemokine-dependent trafficking of immune effector cells. This can boost the efficacy of adoptive T-cell therapy to achieve superior antitumor responses.

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KW - Cancer immunotherapy

KW - Checkpoint blockade

KW - Melanoma

KW - PD-1

KW - PD-L1

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Blockade of the PD-1 pathway enhances the efficacy of adoptive cell therapy against cancer

Abstract

Keywords

ASJC Scopus subject areas

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