Body fatness, adipose tissue compartments, and biomarkers of inflammation and angiogenesis in colorectal cancer: The ColoCare study

Caroline Himbert, Jennifer Ose, Johanna Nattenmüller, Christy A. Warby, Andreana N. Holowatyj, Jürgen Böhm, Tengda Lin, Mariam Haffa, Biljana Gigic, Sheetal Hardikar, Dominique Scherer, Lin Zielske, Petra Schrotz-King, Torsten Kölsch, Erin M. Siegel, David Shibata, Alexis Ulrich, Martin Schneider, Stephen D. Hursting, Hans Ulrich KauczorCornelia M. Ulrich

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Adiposity has been linked to both risk and prognosis of colorectal cancer; however, the impact of different fat areas [visceral (VFA) vs. subcutaneous fat area (SFA)] is unclear. We investigated associations between adiposity and biomarkers of inflammation and angiogenesis among patients with colorectal cancer. Methods: Preoperative serum samples and computed tomography scans were obtained from 188 patients diagnosed with primary invasive stage I–IV colorectal cancer enrolled in the ColoCare Study. Adiposity was assessed by area-based quantification of VFA, SFA, and VFA:SFA ratio on spinal levels L3/L4 and L4/L5. Circulating levels of inflammation (CRP, SAA, sICAM-1, and sVCAM-1) and angiogenesis (VEGF-A and VEGF-D) were assessed from patient sera on the Meso Scale Discovery platform. Partial orrelations and regression analyses, adjusted for age, sex, and tumor stage, were performed. Results: VFA was moderately correlated with CRP and SAA (CRP: L3/L4 and L4/L5:r=0.21, P=0.01; SAA: L3/L4:r=0.17, P = 0.04). The correlation between SFA and the measured biomarkers were weak (r ≤ 0.13, not significant). The ratio of VFA:SFA at L3/L4 was moderately correlated with VEGF-A (r = 0.28, P = 0.0008) and SAA (r = 0.24, P = 0.006), and less so with CRP (r=0.18,P=0.04)and sICAM-1(r=0.18,P=0.04). Similar correlations were found for the VFA:SFA ratio at L4/L5. Conclusions: We observed an association between visceral adiposity and biomarkers of inflammation and angiogenesis in colorectal cancer. In particular, the VFA:SFA ratio was correlated with circulating levels of the proangiogenic biomarker VEGF-A. Impact: Our findings support a direct association of visceral adipose tissue with inflammatory and angiogenic processes, which play fundamental roles in the development and progression of colorectal cancer.

Original languageEnglish (US)
Pages (from-to)76-82
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume28
Issue number1
DOIs
StatePublished - Jan 1 2019

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Subcutaneous Fat
Adipose Tissue
Colorectal Neoplasms
Biomarkers
Inflammation
Adiposity
Vascular Endothelial Growth Factor A
Intra-Abdominal Fat
Vascular Endothelial Growth Factor D
Serum
Tomography
Regression Analysis
Neoplasms

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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Body fatness, adipose tissue compartments, and biomarkers of inflammation and angiogenesis in colorectal cancer : The ColoCare study. / Himbert, Caroline; Ose, Jennifer; Nattenmüller, Johanna; Warby, Christy A.; Holowatyj, Andreana N.; Böhm, Jürgen; Lin, Tengda; Haffa, Mariam; Gigic, Biljana; Hardikar, Sheetal; Scherer, Dominique; Zielske, Lin; Schrotz-King, Petra; Kölsch, Torsten; Siegel, Erin M.; Shibata, David; Ulrich, Alexis; Schneider, Martin; Hursting, Stephen D.; Kauczor, Hans Ulrich; Ulrich, Cornelia M.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 28, No. 1, 01.01.2019, p. 76-82.

Research output: Contribution to journalArticle

Himbert, C, Ose, J, Nattenmüller, J, Warby, CA, Holowatyj, AN, Böhm, J, Lin, T, Haffa, M, Gigic, B, Hardikar, S, Scherer, D, Zielske, L, Schrotz-King, P, Kölsch, T, Siegel, EM, Shibata, D, Ulrich, A, Schneider, M, Hursting, SD, Kauczor, HU & Ulrich, CM 2019, 'Body fatness, adipose tissue compartments, and biomarkers of inflammation and angiogenesis in colorectal cancer: The ColoCare study', Cancer Epidemiology Biomarkers and Prevention, vol. 28, no. 1, pp. 76-82. https://doi.org/10.1158/1055-9965.EPI-18-0654
Himbert, Caroline ; Ose, Jennifer ; Nattenmüller, Johanna ; Warby, Christy A. ; Holowatyj, Andreana N. ; Böhm, Jürgen ; Lin, Tengda ; Haffa, Mariam ; Gigic, Biljana ; Hardikar, Sheetal ; Scherer, Dominique ; Zielske, Lin ; Schrotz-King, Petra ; Kölsch, Torsten ; Siegel, Erin M. ; Shibata, David ; Ulrich, Alexis ; Schneider, Martin ; Hursting, Stephen D. ; Kauczor, Hans Ulrich ; Ulrich, Cornelia M. / Body fatness, adipose tissue compartments, and biomarkers of inflammation and angiogenesis in colorectal cancer : The ColoCare study. In: Cancer Epidemiology Biomarkers and Prevention. 2019 ; Vol. 28, No. 1. pp. 76-82.
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abstract = "Background: Adiposity has been linked to both risk and prognosis of colorectal cancer; however, the impact of different fat areas [visceral (VFA) vs. subcutaneous fat area (SFA)] is unclear. We investigated associations between adiposity and biomarkers of inflammation and angiogenesis among patients with colorectal cancer. Methods: Preoperative serum samples and computed tomography scans were obtained from 188 patients diagnosed with primary invasive stage I–IV colorectal cancer enrolled in the ColoCare Study. Adiposity was assessed by area-based quantification of VFA, SFA, and VFA:SFA ratio on spinal levels L3/L4 and L4/L5. Circulating levels of inflammation (CRP, SAA, sICAM-1, and sVCAM-1) and angiogenesis (VEGF-A and VEGF-D) were assessed from patient sera on the Meso Scale Discovery platform. Partial orrelations and regression analyses, adjusted for age, sex, and tumor stage, were performed. Results: VFA was moderately correlated with CRP and SAA (CRP: L3/L4 and L4/L5:r=0.21, P=0.01; SAA: L3/L4:r=0.17, P = 0.04). The correlation between SFA and the measured biomarkers were weak (r ≤ 0.13, not significant). The ratio of VFA:SFA at L3/L4 was moderately correlated with VEGF-A (r = 0.28, P = 0.0008) and SAA (r = 0.24, P = 0.006), and less so with CRP (r=0.18,P=0.04)and sICAM-1(r=0.18,P=0.04). Similar correlations were found for the VFA:SFA ratio at L4/L5. Conclusions: We observed an association between visceral adiposity and biomarkers of inflammation and angiogenesis in colorectal cancer. In particular, the VFA:SFA ratio was correlated with circulating levels of the proangiogenic biomarker VEGF-A. Impact: Our findings support a direct association of visceral adipose tissue with inflammatory and angiogenic processes, which play fundamental roles in the development and progression of colorectal cancer.",
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T1 - Body fatness, adipose tissue compartments, and biomarkers of inflammation and angiogenesis in colorectal cancer

T2 - The ColoCare study

AU - Himbert, Caroline

AU - Ose, Jennifer

AU - Nattenmüller, Johanna

AU - Warby, Christy A.

AU - Holowatyj, Andreana N.

AU - Böhm, Jürgen

AU - Lin, Tengda

AU - Haffa, Mariam

AU - Gigic, Biljana

AU - Hardikar, Sheetal

AU - Scherer, Dominique

AU - Zielske, Lin

AU - Schrotz-King, Petra

AU - Kölsch, Torsten

AU - Siegel, Erin M.

AU - Shibata, David

AU - Ulrich, Alexis

AU - Schneider, Martin

AU - Hursting, Stephen D.

AU - Kauczor, Hans Ulrich

AU - Ulrich, Cornelia M.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Adiposity has been linked to both risk and prognosis of colorectal cancer; however, the impact of different fat areas [visceral (VFA) vs. subcutaneous fat area (SFA)] is unclear. We investigated associations between adiposity and biomarkers of inflammation and angiogenesis among patients with colorectal cancer. Methods: Preoperative serum samples and computed tomography scans were obtained from 188 patients diagnosed with primary invasive stage I–IV colorectal cancer enrolled in the ColoCare Study. Adiposity was assessed by area-based quantification of VFA, SFA, and VFA:SFA ratio on spinal levels L3/L4 and L4/L5. Circulating levels of inflammation (CRP, SAA, sICAM-1, and sVCAM-1) and angiogenesis (VEGF-A and VEGF-D) were assessed from patient sera on the Meso Scale Discovery platform. Partial orrelations and regression analyses, adjusted for age, sex, and tumor stage, were performed. Results: VFA was moderately correlated with CRP and SAA (CRP: L3/L4 and L4/L5:r=0.21, P=0.01; SAA: L3/L4:r=0.17, P = 0.04). The correlation between SFA and the measured biomarkers were weak (r ≤ 0.13, not significant). The ratio of VFA:SFA at L3/L4 was moderately correlated with VEGF-A (r = 0.28, P = 0.0008) and SAA (r = 0.24, P = 0.006), and less so with CRP (r=0.18,P=0.04)and sICAM-1(r=0.18,P=0.04). Similar correlations were found for the VFA:SFA ratio at L4/L5. Conclusions: We observed an association between visceral adiposity and biomarkers of inflammation and angiogenesis in colorectal cancer. In particular, the VFA:SFA ratio was correlated with circulating levels of the proangiogenic biomarker VEGF-A. Impact: Our findings support a direct association of visceral adipose tissue with inflammatory and angiogenic processes, which play fundamental roles in the development and progression of colorectal cancer.

AB - Background: Adiposity has been linked to both risk and prognosis of colorectal cancer; however, the impact of different fat areas [visceral (VFA) vs. subcutaneous fat area (SFA)] is unclear. We investigated associations between adiposity and biomarkers of inflammation and angiogenesis among patients with colorectal cancer. Methods: Preoperative serum samples and computed tomography scans were obtained from 188 patients diagnosed with primary invasive stage I–IV colorectal cancer enrolled in the ColoCare Study. Adiposity was assessed by area-based quantification of VFA, SFA, and VFA:SFA ratio on spinal levels L3/L4 and L4/L5. Circulating levels of inflammation (CRP, SAA, sICAM-1, and sVCAM-1) and angiogenesis (VEGF-A and VEGF-D) were assessed from patient sera on the Meso Scale Discovery platform. Partial orrelations and regression analyses, adjusted for age, sex, and tumor stage, were performed. Results: VFA was moderately correlated with CRP and SAA (CRP: L3/L4 and L4/L5:r=0.21, P=0.01; SAA: L3/L4:r=0.17, P = 0.04). The correlation between SFA and the measured biomarkers were weak (r ≤ 0.13, not significant). The ratio of VFA:SFA at L3/L4 was moderately correlated with VEGF-A (r = 0.28, P = 0.0008) and SAA (r = 0.24, P = 0.006), and less so with CRP (r=0.18,P=0.04)and sICAM-1(r=0.18,P=0.04). Similar correlations were found for the VFA:SFA ratio at L4/L5. Conclusions: We observed an association between visceral adiposity and biomarkers of inflammation and angiogenesis in colorectal cancer. In particular, the VFA:SFA ratio was correlated with circulating levels of the proangiogenic biomarker VEGF-A. Impact: Our findings support a direct association of visceral adipose tissue with inflammatory and angiogenic processes, which play fundamental roles in the development and progression of colorectal cancer.

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