Body mass index and the risk of head and neck cancer in the Chinese population

Yuji Chen, Yuan Chin Amy Lee, Shuang Li, Qian Li, Chien Jen Chen, Wan Lun Hsu, Pen Jen Lou, Cairong Zhu, Jian Pan, Hongbing Shen, Hongxia Ma, Lin Cai, Baochang He, Yu Wang, Xiaoyan Zhou, Qinghai Ji, Baosen Zhou, Wei Wu, Jie Ma, Daisuke KawakitaPaolo Boffetta, Zuo Feng Zhang, Min Dai, Mia Hashibe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To investigate potential associations between body mass index (BMI) and head and neck cancer (HNC) risk in an East Asian population. Methods: We conducted a hospital-based multicenter case-control study in East Asia including 921 cases and 806 controls. We estimated the odds ratios (ORs) and 95% confidence intervals (95% CI) for HNC risks by using logistic regression, adjusting on potential confounders. Results: Compared to normal BMI at interview (18.5–<25 kg/m 2 ), being underweight (BMI < 18.5 kg/m 2 ) was associated with a higher HNC risk (OR = 2.71, 95% CI 1.40–5.26). Additionally, obesity (BMI > 30 kg/m 2 ) was associated with a lower HNC risk (OR = 0.30, 95% CI 0.16–0.57). Being underweight at age 20 was also associated with an increased risk of HNC. However, being underweight at 5 years or 2 years before interview was not associated with a higher risk of HNC. Conclusion: We observed an inverse association between BMI and HNC risk, which is consistent with previous studies in other geographic regions. Being underweight at age 20 was also associated with a higher risk of HNC, suggesting that reverse causality was not the main source of the association.

Original languageEnglish (US)
Pages (from-to)208-215
Number of pages8
JournalCancer Epidemiology
Volume60
DOIs
StatePublished - Jun 2019

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Head and Neck Neoplasms
Body Mass Index
Thinness
Population
Odds Ratio
Confidence Intervals
Interviews
Far East
Causality
Case-Control Studies
Logistic Models

Keywords

  • BMI
  • East Asia
  • Head and neck cancer risk

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Cancer Research

Cite this

Chen, Y., Lee, Y. C. A., Li, S., Li, Q., Chen, C. J., Hsu, W. L., ... Hashibe, M. (2019). Body mass index and the risk of head and neck cancer in the Chinese population. Cancer Epidemiology, 60, 208-215. https://doi.org/10.1016/j.canep.2019.04.008

Body mass index and the risk of head and neck cancer in the Chinese population. / Chen, Yuji; Lee, Yuan Chin Amy; Li, Shuang; Li, Qian; Chen, Chien Jen; Hsu, Wan Lun; Lou, Pen Jen; Zhu, Cairong; Pan, Jian; Shen, Hongbing; Ma, Hongxia; Cai, Lin; He, Baochang; Wang, Yu; Zhou, Xiaoyan; Ji, Qinghai; Zhou, Baosen; Wu, Wei; Ma, Jie; Kawakita, Daisuke; Boffetta, Paolo; Zhang, Zuo Feng; Dai, Min; Hashibe, Mia.

In: Cancer Epidemiology, Vol. 60, 06.2019, p. 208-215.

Research output: Contribution to journalArticle

Chen, Y, Lee, YCA, Li, S, Li, Q, Chen, CJ, Hsu, WL, Lou, PJ, Zhu, C, Pan, J, Shen, H, Ma, H, Cai, L, He, B, Wang, Y, Zhou, X, Ji, Q, Zhou, B, Wu, W, Ma, J, Kawakita, D, Boffetta, P, Zhang, ZF, Dai, M & Hashibe, M 2019, 'Body mass index and the risk of head and neck cancer in the Chinese population', Cancer Epidemiology, vol. 60, pp. 208-215. https://doi.org/10.1016/j.canep.2019.04.008
Chen, Yuji ; Lee, Yuan Chin Amy ; Li, Shuang ; Li, Qian ; Chen, Chien Jen ; Hsu, Wan Lun ; Lou, Pen Jen ; Zhu, Cairong ; Pan, Jian ; Shen, Hongbing ; Ma, Hongxia ; Cai, Lin ; He, Baochang ; Wang, Yu ; Zhou, Xiaoyan ; Ji, Qinghai ; Zhou, Baosen ; Wu, Wei ; Ma, Jie ; Kawakita, Daisuke ; Boffetta, Paolo ; Zhang, Zuo Feng ; Dai, Min ; Hashibe, Mia. / Body mass index and the risk of head and neck cancer in the Chinese population. In: Cancer Epidemiology. 2019 ; Vol. 60. pp. 208-215.
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abstract = "Objective: To investigate potential associations between body mass index (BMI) and head and neck cancer (HNC) risk in an East Asian population. Methods: We conducted a hospital-based multicenter case-control study in East Asia including 921 cases and 806 controls. We estimated the odds ratios (ORs) and 95{\%} confidence intervals (95{\%} CI) for HNC risks by using logistic regression, adjusting on potential confounders. Results: Compared to normal BMI at interview (18.5–<25 kg/m 2 ), being underweight (BMI < 18.5 kg/m 2 ) was associated with a higher HNC risk (OR = 2.71, 95{\%} CI 1.40–5.26). Additionally, obesity (BMI > 30 kg/m 2 ) was associated with a lower HNC risk (OR = 0.30, 95{\%} CI 0.16–0.57). Being underweight at age 20 was also associated with an increased risk of HNC. However, being underweight at 5 years or 2 years before interview was not associated with a higher risk of HNC. Conclusion: We observed an inverse association between BMI and HNC risk, which is consistent with previous studies in other geographic regions. Being underweight at age 20 was also associated with a higher risk of HNC, suggesting that reverse causality was not the main source of the association.",
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T1 - Body mass index and the risk of head and neck cancer in the Chinese population

AU - Chen, Yuji

AU - Lee, Yuan Chin Amy

AU - Li, Shuang

AU - Li, Qian

AU - Chen, Chien Jen

AU - Hsu, Wan Lun

AU - Lou, Pen Jen

AU - Zhu, Cairong

AU - Pan, Jian

AU - Shen, Hongbing

AU - Ma, Hongxia

AU - Cai, Lin

AU - He, Baochang

AU - Wang, Yu

AU - Zhou, Xiaoyan

AU - Ji, Qinghai

AU - Zhou, Baosen

AU - Wu, Wei

AU - Ma, Jie

AU - Kawakita, Daisuke

AU - Boffetta, Paolo

AU - Zhang, Zuo Feng

AU - Dai, Min

AU - Hashibe, Mia

PY - 2019/6

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N2 - Objective: To investigate potential associations between body mass index (BMI) and head and neck cancer (HNC) risk in an East Asian population. Methods: We conducted a hospital-based multicenter case-control study in East Asia including 921 cases and 806 controls. We estimated the odds ratios (ORs) and 95% confidence intervals (95% CI) for HNC risks by using logistic regression, adjusting on potential confounders. Results: Compared to normal BMI at interview (18.5–<25 kg/m 2 ), being underweight (BMI < 18.5 kg/m 2 ) was associated with a higher HNC risk (OR = 2.71, 95% CI 1.40–5.26). Additionally, obesity (BMI > 30 kg/m 2 ) was associated with a lower HNC risk (OR = 0.30, 95% CI 0.16–0.57). Being underweight at age 20 was also associated with an increased risk of HNC. However, being underweight at 5 years or 2 years before interview was not associated with a higher risk of HNC. Conclusion: We observed an inverse association between BMI and HNC risk, which is consistent with previous studies in other geographic regions. Being underweight at age 20 was also associated with a higher risk of HNC, suggesting that reverse causality was not the main source of the association.

AB - Objective: To investigate potential associations between body mass index (BMI) and head and neck cancer (HNC) risk in an East Asian population. Methods: We conducted a hospital-based multicenter case-control study in East Asia including 921 cases and 806 controls. We estimated the odds ratios (ORs) and 95% confidence intervals (95% CI) for HNC risks by using logistic regression, adjusting on potential confounders. Results: Compared to normal BMI at interview (18.5–<25 kg/m 2 ), being underweight (BMI < 18.5 kg/m 2 ) was associated with a higher HNC risk (OR = 2.71, 95% CI 1.40–5.26). Additionally, obesity (BMI > 30 kg/m 2 ) was associated with a lower HNC risk (OR = 0.30, 95% CI 0.16–0.57). Being underweight at age 20 was also associated with an increased risk of HNC. However, being underweight at 5 years or 2 years before interview was not associated with a higher risk of HNC. Conclusion: We observed an inverse association between BMI and HNC risk, which is consistent with previous studies in other geographic regions. Being underweight at age 20 was also associated with a higher risk of HNC, suggesting that reverse causality was not the main source of the association.

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