TY - JOUR
T1 - Body mass index mediates the prognostic significance of circulating tumor cells in inflammatory breast cancer
AU - Fayanju, Oluwadamilola M.
AU - Hall, Carolyn S.
AU - Bauldry, Jessica Bowman
AU - Karhade, Mandar
AU - Valad, Lily M.
AU - Kuerer, Henry M.
AU - DeSnyder, Sarah M.
AU - Barcenas, Carlos H.
AU - Lucci, Anthony
N1 - Publisher Copyright:
© 2017
PY - 2017/10
Y1 - 2017/10
N2 - Background Obesity (BMI≥30) may be an etiologic and prognostic factor in inflammatory breast cancer (IBC). We examined the relationship between BMI, pathologic complete response (pCR), and circulating-tumor-cell (CTC) levels in IBC. Methods Cohort included IBC patients diagnosed 2005–2015 who had neoadjuvant chemotherapy during a prospective trial on CTCs and pathologic review describing pCR. Chi-square, logistic regression, and Cox proportional hazards models were used to identify clinicopathologic associations with event-free survival (EFS). Results Of 73 patients, 61 (84%) had CTC values, 22 (30%) achieved a pCR, and 39 (53%) were obese. There was no difference between obese and non-obese patients for pCR rates (31% vs. 29%, p = 0.90) or presence of CTCs (23% vs. 26%, p = 0.80). Among non-obese patients, CTCs were associated with worse EFS (HR 11.69, p < 0.01), but among obese patients, there was no difference in EFS between those with and without CTCs. Conclusions BMI mediates CTCs' prognostic significance in IBC.
AB - Background Obesity (BMI≥30) may be an etiologic and prognostic factor in inflammatory breast cancer (IBC). We examined the relationship between BMI, pathologic complete response (pCR), and circulating-tumor-cell (CTC) levels in IBC. Methods Cohort included IBC patients diagnosed 2005–2015 who had neoadjuvant chemotherapy during a prospective trial on CTCs and pathologic review describing pCR. Chi-square, logistic regression, and Cox proportional hazards models were used to identify clinicopathologic associations with event-free survival (EFS). Results Of 73 patients, 61 (84%) had CTC values, 22 (30%) achieved a pCR, and 39 (53%) were obese. There was no difference between obese and non-obese patients for pCR rates (31% vs. 29%, p = 0.90) or presence of CTCs (23% vs. 26%, p = 0.80). Among non-obese patients, CTCs were associated with worse EFS (HR 11.69, p < 0.01), but among obese patients, there was no difference in EFS between those with and without CTCs. Conclusions BMI mediates CTCs' prognostic significance in IBC.
KW - Body mass index
KW - Circulating tumor cells
KW - Inflammatory breast cancer
KW - Obesity
KW - Pathologic complete response
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=85023611850&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85023611850&partnerID=8YFLogxK
U2 - 10.1016/j.amjsurg.2017.06.005
DO - 10.1016/j.amjsurg.2017.06.005
M3 - Article
C2 - 28720217
AN - SCOPUS:85023611850
SN - 0002-9610
VL - 214
SP - 666
EP - 671
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 4
ER -