Bone marrow findings in systemic lupus erythematosus patients with peripheral cytopenias

R. M.R. Pereira, E. R.P. Velloso, Y. Menezes, S. Gualandro, José Vassallo, N. H. Yoshinari

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    56 Scopus citations


    We studied 21 bone marrow specimens from 21 patients with systemic lupus erythematosus (SLE) and peripheral cytopenias: anaemia (Hb<10 g/dl), and/or leucopenia (white blood cell count <4 x 109/l), and/or thrombocytopenia (platelets <150 x 109/l). None of the patients had used immunosuppressive drugs in the 2 months before the study, and 11 (52.4%) had never used these drugs. The global and specific series cellularity, degree of fibrosis and necrosis were evaluated by bone marrow trephine; morphological abnormalities and iron stores were evaluated by cytological smears. The most important abnormalities viewed in bone marrow biopsies were: global hypocellularity (47.6%), increased reticulin proliferation (76.2%) with myelofibrosis in one patient, and necrosis (19.0%). The marrow aspirates were difficult to obtain in four patients, who showed an increased reticulin proliferation on histological analysis. Plasmocytosis was present in 26.7% of cases and in one there was a serum monoclonal component (IgG kappa). Iron stores were normal or increased in 26.7% of specimens and decreased or absent in 73.3%. The most frequent peripheral abnormality was leucopenia in 90.4% (19/21) and granulocytic hypoplasia was observed in 47.3% (9/19) of these patients. We conclude that the bone marrow may be a target organ in SLE with cytopenias.

    Original languageEnglish (US)
    Pages (from-to)219-222
    Number of pages4
    JournalClinical Rheumatology
    Issue number3
    StatePublished - Aug 5 1998


    • Bone marrow
    • Cytopenia
    • Systemic lupus erythematosus

    ASJC Scopus subject areas

    • Rheumatology

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    Pereira, R. M. R., Velloso, E. R. P., Menezes, Y., Gualandro, S., Vassallo, J., & Yoshinari, N. H. (1998). Bone marrow findings in systemic lupus erythematosus patients with peripheral cytopenias. Clinical Rheumatology, 17(3), 219-222.