TY - JOUR
T1 - Boron Neutron Capture Therapy
T2 - A Review of Clinical Applications
AU - Malouff, Timothy D.
AU - Seneviratne, Danushka S.
AU - Ebner, Daniel K.
AU - Stross, William C.
AU - Waddle, Mark R.
AU - Trifiletti, Daniel M.
AU - Krishnan, Sunil
N1 - Publisher Copyright:
© Copyright © 2021 Malouff, Seneviratne, Ebner, Stross, Waddle, Trifiletti and Krishnan.
PY - 2021/2/26
Y1 - 2021/2/26
N2 - Boron neutron capture therapy (BNCT) is an emerging treatment modality aimed at improving the therapeutic ratio for traditionally difficult to treat tumors. BNCT utilizes boronated agents to preferentially deliver boron-10 to tumors, which, after undergoing irradiation with neutrons, yields litihium-7 and an alpha particle. The alpha particle has a short range, therefore preferentially affecting tumor tissues while sparing more distal normal tissues. To date, BNCT has been studied clinically in a variety of disease sites, including glioblastoma multiforme, meningioma, head and neck cancers, lung cancers, breast cancers, hepatocellular carcinoma, sarcomas, cutaneous malignancies, extramammary Paget’s disease, recurrent cancers, pediatric cancers, and metastatic disease. We aim to provide an up-to-date and comprehensive review of the studies of each of these disease sites, as well as a review on the challenges facing adoption of BNCT.
AB - Boron neutron capture therapy (BNCT) is an emerging treatment modality aimed at improving the therapeutic ratio for traditionally difficult to treat tumors. BNCT utilizes boronated agents to preferentially deliver boron-10 to tumors, which, after undergoing irradiation with neutrons, yields litihium-7 and an alpha particle. The alpha particle has a short range, therefore preferentially affecting tumor tissues while sparing more distal normal tissues. To date, BNCT has been studied clinically in a variety of disease sites, including glioblastoma multiforme, meningioma, head and neck cancers, lung cancers, breast cancers, hepatocellular carcinoma, sarcomas, cutaneous malignancies, extramammary Paget’s disease, recurrent cancers, pediatric cancers, and metastatic disease. We aim to provide an up-to-date and comprehensive review of the studies of each of these disease sites, as well as a review on the challenges facing adoption of BNCT.
KW - boron neutron capture
KW - boron neutron capture therapy (BNCT)
KW - fast neutrons
KW - particles
KW - radiation
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U2 - 10.3389/fonc.2021.601820
DO - 10.3389/fonc.2021.601820
M3 - Review article
C2 - 33718149
AN - SCOPUS:85102467928
SN - 2234-943X
VL - 11
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 601820
ER -