TY - JOUR
T1 - Breaking Down Barriers to Chemoresistance
T2 - Role of Chemotherapy-Induced Osteoblastic Jagged1
AU - Mohammad, Khalid S.
AU - Guise, Theresa A.
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/12/11
Y1 - 2017/12/11
N2 - Bone metastases are incurable. The bone microenvironment has always been a suspect for this clinical enigma, but the exact mechanisms have been unclear. In this issue of Cancer Cell, Zheng and colleagues provide evidence that chemotherapy itself induces chemoresistance of bone metastases, mediated by osteoblast Jagged1-induced tumor Notch signaling. Bone metastases are incurable. The bone microenvironment has always been a suspect for this clinical enigma, but the exact mechanisms have been unclear. In this issue of Cancer Cell, Zheng and colleagues provide evidence that chemotherapy itself induces chemoresistance of bone metastases, mediated by osteoblast Jagged1-induced tumor Notch signaling.
AB - Bone metastases are incurable. The bone microenvironment has always been a suspect for this clinical enigma, but the exact mechanisms have been unclear. In this issue of Cancer Cell, Zheng and colleagues provide evidence that chemotherapy itself induces chemoresistance of bone metastases, mediated by osteoblast Jagged1-induced tumor Notch signaling. Bone metastases are incurable. The bone microenvironment has always been a suspect for this clinical enigma, but the exact mechanisms have been unclear. In this issue of Cancer Cell, Zheng and colleagues provide evidence that chemotherapy itself induces chemoresistance of bone metastases, mediated by osteoblast Jagged1-induced tumor Notch signaling.
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U2 - 10.1016/j.ccell.2017.11.016
DO - 10.1016/j.ccell.2017.11.016
M3 - Short survey
C2 - 29232546
AN - SCOPUS:85037039715
SN - 1535-6108
VL - 32
SP - 717
EP - 718
JO - Cancer cell
JF - Cancer cell
IS - 6
ER -