Brief Report: Recurrence of Anal High-Grade Squamous Intraepithelial Lesions among Women Living with HIV

Elizabeth A. Stier, Wafaa Abbasi, Amma F. Agyemang, Eduardo Amílkar Valle Álvarez, Elizabeth Y. Chiao, Ashish A. Deshmukh

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background:Women living with HIV (WLHIV) have a high risk of developing invasive anal cancer. Anal cancer may be prevented with early detection and treatment of anal histologic high-grade squamous intraepithelial lesions (HSIL). However, there are limited data on the efficacy of anal HSIL treatment in WLHIV.Study design:We conducted a retrospective study of WLHIV treated for anal HSIL under high-resolution anoscopy (HRA) guidance from January 1, 2007 to December 31, 2017 with at least one post-treatment visit at an urban tertiary care hospital.Results:Forty-five WLHIV women with at least 1 follow-up evaluation after treatment for anal HSIL were identified. The median age was 46 years (range 35-66 years), 63% were African American, 27% were Hispanic/Latino, and 53% were current smokers. The mean absolute CD4+T-cell count was 516 cells/mm3; 50% and 24% of the cohort had a history of cervical or vulvar HSIL respectively. The cumulative probability of anal HSIL recurrence was 29% at 12 months, 52% at 24 months, and 79% at 36 months post-treatment.Conclusion:Most WLHIV treated for anal HSIL recurred within 3 years, suggesting need for continued surveillance after treatment. Our data contribute to the information needed to develop effective anal cancer prevention guidelines in WLHIV.

Original languageEnglish (US)
Pages (from-to)66-69
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Volume84
Issue number1
DOIs
StatePublished - May 1 2020
Externally publishedYes

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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