Building p53

Tamara Terzian, Guillermina Lozano

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The intricacies of p53 regulation just got more complex. While much is known about the transcriptional regulation of p53 target genes, Chen and Kastan (pp. 2146-2156) uncovered a new mechanism regarding the making of the p53 protein itself. In the October 1, 2010, issue of Genes & Development, they introduced us to a novel mechanism of p53 translational control, by which a 5′-3′ cap-independent, poly(A)-independent, RNA-RNA interaction enhances p53 translation by binding the ribosomal protein RPL26 following DNA damage. Oligonucleotides designed against this 5′-3′ untranslated region (UTR) duplex disrupted the binding of RPL26 to p53 mRNA and reduced p53 synthesis and, therefore, function. This study reveals an alternate mechanism of translational control to regulate p53 levels.

Original languageEnglish (US)
Pages (from-to)2229-2232
Number of pages4
JournalGenes and Development
Volume24
Issue number20
DOIs
StatePublished - Oct 15 2010

Keywords

  • Cytoprotection
  • DNA damage
  • Translational control
  • p53

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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