Bupropion-SR for smoking cessation in early recovery from alcohol dependence: A placebo-controlled, double-blind pilot study

Maher Karam-Hage, Stephen Strobbe, Jason D. Robinson, Kirk J. Brower

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We conducted a double-blind pilot study involving 11 alcohol- and nicotine-dependent patients randomized to receive either bupropion or placebo. Four of six patients on bupropion and one of five patients on placebo were abstinent from smoking at the end of medication phase. Those in the bupropion group reported significantly less craving (p < .02) and less exposure to cigarette smoke over time (expired carbon monoxide; p < .01). There were no serious adverse events and no main effects of medication group on either per subject or total number of adverse events. All those who completed treatment remained abstinent from alcohol.

Original languageEnglish (US)
Pages (from-to)487-490
Number of pages4
JournalAmerican Journal of Drug and Alcohol Abuse
Volume37
Issue number6
DOIs
StatePublished - Nov 2011

Keywords

  • alcohol dependence
  • bupropion
  • smoking cessation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health

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