BV/ODV-E26: A palmitoylated, multifunctional structural protein of Autographa californica nucleopolyhedrovirus

Jared K. Burks; Max D. Summers; Sharon C. Braunagel

doi:10.1016/j.virol.2006.11.007

BV/ODV-E26: A palmitoylated, multifunctional structural protein of Autographa californica nucleopolyhedrovirus

Jared K. Burks
, Max D. Summers
, Sharon C. Braunagel

Leukemia

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Autographa californica nucleopolyhedrovirus Ac16 is 1 of 17 genes conserved within Type 1 nucleopolyhedroviruses. This report demonstrates that multiple isoforms of the protein encoded by Ac16, BV/ODV-E26 (E26), are present in the infected cell. One form of E26 associates with viral DNA or DNA-binding proteins, while a second form associates with intracellular membranes and this is likely due to palmitoylation. The different forms of E26 present unique epitopes that can be discriminated by antiserum produced to bacterially or virally produced antigen. A summation of the data now available on E26 suggests that it is a multifunctional protein and the functional states assume unique conformations that can be discriminated by differing antisera.

Original language	English (US)
Pages (from-to)	194-203
Number of pages	10
Journal	Virology
Volume	361
Issue number	1
DOIs	https://doi.org/10.1016/j.virol.2006.11.007
State	Published - Apr 25 2007

Keywords

Baculovirus
Membrane protein
Palmitoylation

ASJC Scopus subject areas

Virology

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10.1016/j.virol.2006.11.007

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@article{2543a5afe1824343b17eae2088cdd821,

title = "BV/ODV-E26: A palmitoylated, multifunctional structural protein of Autographa californica nucleopolyhedrovirus",

abstract = "Autographa californica nucleopolyhedrovirus Ac16 is 1 of 17 genes conserved within Type 1 nucleopolyhedroviruses. This report demonstrates that multiple isoforms of the protein encoded by Ac16, BV/ODV-E26 (E26), are present in the infected cell. One form of E26 associates with viral DNA or DNA-binding proteins, while a second form associates with intracellular membranes and this is likely due to palmitoylation. The different forms of E26 present unique epitopes that can be discriminated by antiserum produced to bacterially or virally produced antigen. A summation of the data now available on E26 suggests that it is a multifunctional protein and the functional states assume unique conformations that can be discriminated by differing antisera.",

keywords = "Baculovirus, Membrane protein, Palmitoylation",

author = "Burks, \{Jared K.\} and Summers, \{Max D.\} and Braunagel, \{Sharon C.\}",

note = "Funding Information: We thank L. Miller (deceased) for the vDa26z virus, I. Imai (Laboratory of Molecular Entomology and Baculovirology, Hirosawa, Japan) for Bm8 antibody and L. Volkman (U. California, Berkeley) for the AcV1 antibody. This article was submitted by J.K.B. in partial fulfillment of the PhD degree at Texas A\&M University. This work was supported by the Texas Agricultural Experiment Station Project Grant TEXO-08078 (M.D.S.).",

year = "2007",

month = apr,

day = "25",

doi = "10.1016/j.virol.2006.11.007",

language = "English (US)",

volume = "361",

pages = "194--203",

journal = "Virology",

issn = "0042-6822",

publisher = "Academic Press Inc.",

number = "1",

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T1 - BV/ODV-E26

T2 - A palmitoylated, multifunctional structural protein of Autographa californica nucleopolyhedrovirus

AU - Burks, Jared K.

AU - Summers, Max D.

AU - Braunagel, Sharon C.

N1 - Funding Information: We thank L. Miller (deceased) for the vDa26z virus, I. Imai (Laboratory of Molecular Entomology and Baculovirology, Hirosawa, Japan) for Bm8 antibody and L. Volkman (U. California, Berkeley) for the AcV1 antibody. This article was submitted by J.K.B. in partial fulfillment of the PhD degree at Texas A&M University. This work was supported by the Texas Agricultural Experiment Station Project Grant TEXO-08078 (M.D.S.).

PY - 2007/4/25

Y1 - 2007/4/25

N2 - Autographa californica nucleopolyhedrovirus Ac16 is 1 of 17 genes conserved within Type 1 nucleopolyhedroviruses. This report demonstrates that multiple isoforms of the protein encoded by Ac16, BV/ODV-E26 (E26), are present in the infected cell. One form of E26 associates with viral DNA or DNA-binding proteins, while a second form associates with intracellular membranes and this is likely due to palmitoylation. The different forms of E26 present unique epitopes that can be discriminated by antiserum produced to bacterially or virally produced antigen. A summation of the data now available on E26 suggests that it is a multifunctional protein and the functional states assume unique conformations that can be discriminated by differing antisera.

AB - Autographa californica nucleopolyhedrovirus Ac16 is 1 of 17 genes conserved within Type 1 nucleopolyhedroviruses. This report demonstrates that multiple isoforms of the protein encoded by Ac16, BV/ODV-E26 (E26), are present in the infected cell. One form of E26 associates with viral DNA or DNA-binding proteins, while a second form associates with intracellular membranes and this is likely due to palmitoylation. The different forms of E26 present unique epitopes that can be discriminated by antiserum produced to bacterially or virally produced antigen. A summation of the data now available on E26 suggests that it is a multifunctional protein and the functional states assume unique conformations that can be discriminated by differing antisera.

KW - Baculovirus

KW - Membrane protein

KW - Palmitoylation

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U2 - 10.1016/j.virol.2006.11.007

DO - 10.1016/j.virol.2006.11.007

M3 - Article

C2 - 17169392

AN - SCOPUS:34047249946

SN - 0042-6822

VL - 361

SP - 194

EP - 203

JO - Virology

JF - Virology

IS - 1

ER -

BV/ODV-E26: A palmitoylated, multifunctional structural protein of Autographa californica nucleopolyhedrovirus

Abstract

Keywords

ASJC Scopus subject areas

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