TY - JOUR
T1 - Cancer and diet
T2 - How are they related?
AU - Sung, Bokyung
AU - Prasad, Sahdeo
AU - Yadav, Vivek R.
AU - Lavasanifar, Afsaneh
AU - Aggarwal, Bharat B.
N1 - Funding Information:
This work was supported by a grant from New Chapter, a core grant from the National Institutes of Health (CA-16 672), a program project grant from National Institutes of Health (NIH CA-124787-01A2) and a grant from the Center for Targeted Therapy of the University of Texas M.D. Anderson Cancer Center. The authors report no conflicts of interest.The authors alone are responsible for the content and writing of the paper.
PY - 2011/8
Y1 - 2011/8
N2 - Extensive research in the past decade has revealed cancer to be a multigenic disease caused by perturbation of multiple cell signalling pathways and dysregulation of numerous gene products, all of which have been linked to inflammation. It is also becoming evident that various lifestyle factors, such as tobacco and alcohol use, diet, environmental pollution, radiation and infections, can cause chronic inflammation and lead to tumourigenesis. Chronic diseases caused by ongoing inflammation therefore require chronic, not acute, treatment. Nutraceuticals, compounds derived from fruits, vegetables, spices and cereals, can be used chronically. This study discusses the molecular targets of some nutraceuticals that happen to be markers of chronic inflammation and how they can prevent or treat cancer. These naturally-occurring agents in the diet have great potential as anti-cancer drugs, thus proving Hippocrates, who proclaimed 25 centuries ago, 'â€̃Let food be thy medicine and medicine be thy food'’.
AB - Extensive research in the past decade has revealed cancer to be a multigenic disease caused by perturbation of multiple cell signalling pathways and dysregulation of numerous gene products, all of which have been linked to inflammation. It is also becoming evident that various lifestyle factors, such as tobacco and alcohol use, diet, environmental pollution, radiation and infections, can cause chronic inflammation and lead to tumourigenesis. Chronic diseases caused by ongoing inflammation therefore require chronic, not acute, treatment. Nutraceuticals, compounds derived from fruits, vegetables, spices and cereals, can be used chronically. This study discusses the molecular targets of some nutraceuticals that happen to be markers of chronic inflammation and how they can prevent or treat cancer. These naturally-occurring agents in the diet have great potential as anti-cancer drugs, thus proving Hippocrates, who proclaimed 25 centuries ago, 'â€̃Let food be thy medicine and medicine be thy food'’.
KW - Cancer
KW - Dietary agents
KW - Inflammation
UR - https://www.scopus.com/pages/publications/79960098233
UR - https://www.scopus.com/pages/publications/79960098233#tab=citedBy
U2 - 10.3109/10715762.2011.582869
DO - 10.3109/10715762.2011.582869
M3 - Article
C2 - 21651450
AN - SCOPUS:79960098233
SN - 1071-5762
VL - 45
SP - 864
EP - 879
JO - Free Radical Research
JF - Free Radical Research
IS - 8
ER -