Cancer biology: Gone but not forgotten

Norman E. Sharpless; Ronald A. DePinho

doi:10.1038/nature05567

Cancer biology: Gone but not forgotten

Norman E. Sharpless
, Ronald A. DePinho

Research output: Contribution to journal › Short survey › peer-review

32 Scopus citations

Abstract

The p53 tumour-suppressor protein is a cell's principal guardian against cancer. Most cancers eliminate p53 - but it seems that its pathway remains intact, so resurrecting it might provide a cancer therapy.

Original language	English (US)
Pages (from-to)	606-607
Number of pages	2
Journal	Nature
Volume	445
Issue number	7128
DOIs	https://doi.org/10.1038/nature05567
State	Published - Feb 8 2007
Externally published	Yes

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title = "Cancer biology: Gone but not forgotten",

abstract = "The p53 tumour-suppressor protein is a cell's principal guardian against cancer. Most cancers eliminate p53 - but it seems that its pathway remains intact, so resurrecting it might provide a cancer therapy.",

author = "Sharpless, \{Norman E.\} and DePinho, \{Ronald A.\}",

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T1 - Cancer biology

T2 - Gone but not forgotten

AU - Sharpless, Norman E.

AU - DePinho, Ronald A.

PY - 2007/2/8

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N2 - The p53 tumour-suppressor protein is a cell's principal guardian against cancer. Most cancers eliminate p53 - but it seems that its pathway remains intact, so resurrecting it might provide a cancer therapy.

AB - The p53 tumour-suppressor protein is a cell's principal guardian against cancer. Most cancers eliminate p53 - but it seems that its pathway remains intact, so resurrecting it might provide a cancer therapy.

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U2 - 10.1038/nature05567

DO - 10.1038/nature05567

M3 - Short survey

C2 - 17251931

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VL - 445

SP - 606

EP - 607

JO - Nature

JF - Nature

IS - 7128

ER -

Cancer biology: Gone but not forgotten

Abstract

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