Cancer chemoprotective effects of Curcuma xanthorrhiza

Hee Park Jae, Kyun Park Kwang, Jeong Kim Mi, Kwan Hwang Jae, Kyu Park Sun, Yoon Chung Won

    Research output: Contribution to journalArticlepeer-review

    15 Scopus citations

    Abstract

    Curcuma xanthorrhiza Roxb. (Zingiberaceae) is a medicinal plant widely spread in South East Asia. In particular, it is commonly used not only for food and medicinal purposes in Indonesia, but also for the topical treatment of acne and skin inflammations as Thai traditional medicine. It was found that the methanol extract of C. xanthorrhiza inhibited significantly 7,12-dimethylbenz[a] anthracene (DMBA)-induced bacterial mutagenesis of Salmonella typhimurium TA98 and TA100 in the presence of S9, and the mutagenesis induced by H 2O2 and tert-butylhydroperoxide in S. typhimurium TA102, respectively. In addition, 12-O-tetradecanolyphorbol-13-acetate(TPA)-induced mouse ear edema was markedly inhibited by pretreatment with C. xanthorrhiza extract. C. xanthorrhiza extract dose-dependently reduced ODC expression in mouse skin with TPA-induced acute inflammation. Furthermore, repeated treatment with 0.1% C. xanthorrhiza extract reduced the average number of tumors per mouse and the percentage of tumor-bearing mice in a multistage mouse skin carcinogenesis induced by DMBA and TPA. These results demonstrate that the methanol extract of C. xanthorrhiza possesses cancer chemopreventive potential.

    Original languageEnglish (US)
    Pages (from-to)695-698
    Number of pages4
    JournalPhytotherapy Research
    Volume22
    Issue number5
    DOIs
    StatePublished - May 1 2008

    Keywords

    • Antiinflammatory activity
    • Antimutagenicity
    • Chemoprevention
    • Curcuma xanthorrhiza
    • Multistage skin carcinogenesis

    ASJC Scopus subject areas

    • Pharmacology

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