Cancer chromosomes in crisis

Ronald A. DePinho; Kornelia Polyak

doi:10.1038/ng0904-932

Cancer chromosomes in crisis

Ronald A. DePinho, Kornelia Polyak

Research output: Contribution to journal › Short survey › peer-review

81 Scopus citations

Abstract

The benign-to-malignant transition in human breast cancer is associated with a marked increase in chromosomal aberrations. A new study suggests that telomere dysfunction and its associated bridge-fusion-breakage cycles may drive this episodic instability, thereby providing aspiring cancer cells with the multiple genetic aberrations needed to achieve a fully malignant state.

Original language	English (US)
Pages (from-to)	932-934
Number of pages	3
Journal	Nature Genetics
Volume	36
Issue number	9
DOIs	https://doi.org/10.1038/ng0904-932
State	Published - Sep 2004
Externally published	Yes

ASJC Scopus subject areas

Genetics

Access to Document

10.1038/ng0904-932

Cite this

@article{781fcddf36eb4a3bbd71a33272213fe1,

title = "Cancer chromosomes in crisis",

abstract = "The benign-to-malignant transition in human breast cancer is associated with a marked increase in chromosomal aberrations. A new study suggests that telomere dysfunction and its associated bridge-fusion-breakage cycles may drive this episodic instability, thereby providing aspiring cancer cells with the multiple genetic aberrations needed to achieve a fully malignant state.",

author = "DePinho, {Ronald A.} and Kornelia Polyak",

year = "2004",

month = sep,

doi = "10.1038/ng0904-932",

language = "English (US)",

volume = "36",

pages = "932--934",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "9",

}

TY - JOUR

T1 - Cancer chromosomes in crisis

AU - DePinho, Ronald A.

AU - Polyak, Kornelia

PY - 2004/9

Y1 - 2004/9

N2 - The benign-to-malignant transition in human breast cancer is associated with a marked increase in chromosomal aberrations. A new study suggests that telomere dysfunction and its associated bridge-fusion-breakage cycles may drive this episodic instability, thereby providing aspiring cancer cells with the multiple genetic aberrations needed to achieve a fully malignant state.

AB - The benign-to-malignant transition in human breast cancer is associated with a marked increase in chromosomal aberrations. A new study suggests that telomere dysfunction and its associated bridge-fusion-breakage cycles may drive this episodic instability, thereby providing aspiring cancer cells with the multiple genetic aberrations needed to achieve a fully malignant state.

UR - http://www.scopus.com/inward/record.url?scp=4444226253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4444226253&partnerID=8YFLogxK

U2 - 10.1038/ng0904-932

DO - 10.1038/ng0904-932

M3 - Short survey

C2 - 15340427

AN - SCOPUS:4444226253

SN - 1061-4036

VL - 36

SP - 932

EP - 934

JO - Nature Genetics

JF - Nature Genetics

IS - 9

ER -

Cancer chromosomes in crisis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this