Abstract
Advances in cancer genomics have been propelled by the steady evolution of molecular profiling technologies. Over the past decade, high-throughput sequencing technologies have matured to the point necessary to support disease-specific shotgun sequencing. This has compelled whole-genome sequencing studies across a broad panel of malignancies. The emergence of high-throughput sequencing technologies has inspired new chemical and computational techniques enabling interrogation of cancer-specific genomic and transcriptomic variants, previously unannotated genes, and chromatin structure. Finally, recent progress in single-cell sequencing holds great promise for studies interrogating the consequences of tumor evolution in cancers presenting with genomic heterogeneity.
Original language | English (US) |
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Pages (from-to) | 152-160 |
Number of pages | 9 |
Journal | Cancer Letters |
Volume | 340 |
Issue number | 2 |
DOIs | |
State | Published - Nov 1 2013 |
Keywords
- Bioinformatics
- Cancer genomics
- Chromosomal conformation sequencing
- Next-generation sequencing
- Transcriptomics
- Tumor heterogeneity
ASJC Scopus subject areas
- Oncology
- Cancer Research