Cancer genome sequencing: Understanding malignancy as a disease of the genome, its conformation, and its evolution

Lalit R. Patel, Matti Nykter, Kexin Chen, Wei Zhang

Research output: Contribution to journalShort survey

14 Scopus citations

Abstract

Advances in cancer genomics have been propelled by the steady evolution of molecular profiling technologies. Over the past decade, high-throughput sequencing technologies have matured to the point necessary to support disease-specific shotgun sequencing. This has compelled whole-genome sequencing studies across a broad panel of malignancies. The emergence of high-throughput sequencing technologies has inspired new chemical and computational techniques enabling interrogation of cancer-specific genomic and transcriptomic variants, previously unannotated genes, and chromatin structure. Finally, recent progress in single-cell sequencing holds great promise for studies interrogating the consequences of tumor evolution in cancers presenting with genomic heterogeneity.

Original languageEnglish (US)
Pages (from-to)152-160
Number of pages9
JournalCancer Letters
Volume340
Issue number2
DOIs
StatePublished - Nov 1 2013

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Keywords

  • Bioinformatics
  • Cancer genomics
  • Chromosomal conformation sequencing
  • Next-generation sequencing
  • Transcriptomics
  • Tumor heterogeneity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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