TY - JOUR
T1 - Cancer invasion into musculature
T2 - Mechanics, molecules and implications
AU - Beunk, Lianne
AU - Brown, Kari
AU - Nagtegaal, Iris
AU - Friedl, Peter
AU - Wolf, Katarina
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2019/9
Y1 - 2019/9
N2 - Tumor invasion along structural interphases of surrounding tumor-free tissue represents a key process during tumor progression. Much attention has been devoted to mechanisms of tumor cell migration within extracellular matrix (ECM)-rich connective tissue, however a comprehensive understanding of tumor invasion into tissue of higher structural complexity, such as muscle tissue, is lacking. Muscle invasion in cancer patients is often associated with destructive growth and worsened prognosis. Here, we review biochemical, geometrical and mechanical cues of smooth and skeletal muscle tissues and their relevance for guided invasion of cancer cells. As integrating concept, muscle-organizing ECM-rich surfaces of the epi-, peri- and endomysium provide cleft-like confined spaces along interfaces between dynamic muscle cells, which provide molecular and physical cues that guide migrating cancer cells, forming a possible contribution to cancer progression.
AB - Tumor invasion along structural interphases of surrounding tumor-free tissue represents a key process during tumor progression. Much attention has been devoted to mechanisms of tumor cell migration within extracellular matrix (ECM)-rich connective tissue, however a comprehensive understanding of tumor invasion into tissue of higher structural complexity, such as muscle tissue, is lacking. Muscle invasion in cancer patients is often associated with destructive growth and worsened prognosis. Here, we review biochemical, geometrical and mechanical cues of smooth and skeletal muscle tissues and their relevance for guided invasion of cancer cells. As integrating concept, muscle-organizing ECM-rich surfaces of the epi-, peri- and endomysium provide cleft-like confined spaces along interfaces between dynamic muscle cells, which provide molecular and physical cues that guide migrating cancer cells, forming a possible contribution to cancer progression.
KW - Cancer progression
KW - Extracellular matrix
KW - Guided cell migration
KW - Smooth/skeletal muscle tissue
KW - Tumour invasion
UR - http://www.scopus.com/inward/record.url?scp=85052799835&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052799835&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2018.07.014
DO - 10.1016/j.semcdb.2018.07.014
M3 - Review article
C2 - 30009945
AN - SCOPUS:85052799835
SN - 1084-9521
VL - 93
SP - 36
EP - 45
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
ER -