TY - JOUR
T1 - canSAR
T2 - An integrated cancer public translational research and drug discovery resource
AU - Halling-Brown, Mark D.
AU - Bulusu, Krishna C.
AU - Patel, Mishal
AU - Tym, Joe E.
AU - Al-Lazikani, Bissan
N1 - Funding Information:
canSAR is running on an Apache web server implemented in PHP, Javascript, Perl and Java. The data reside in an Oracle 11g database. Chemical compound search and handling is supported by the Accelrys direct cartridge. The data processing pipelines are written in Perl, Python and Java and utilize Openbabel, CDK (41) and Pipeline Pilot (Accelrys Inc).
PY - 2012/1
Y1 - 2012/1
N2 - canSAR is a fully integrated cancer research and drug discovery resource developed to utilize the growing publicly available biological annotation, chemical screening, RNA interference screening, expression, amplification and 3D structural data. Scientists can, in a single place, rapidly identify biological annotation of a target, its structural characterization, expression levels and protein interaction data, as well as suitable cell lines for experiments, potential tool compounds and similarity to known drug targets. canSAR has, from the outset, been completely use-case driven which has dramatically influenced the design of the back-end and the functionality provided through the interfaces. The Web interface at http://cansar.icr.ac.uk provides flexible, multipoint entry into canSAR. This allows easy access to the multidisciplinary data within, including target and compound synopses, bioactivity views and expert tools for chemogenomic, expression and protein interaction network data.
AB - canSAR is a fully integrated cancer research and drug discovery resource developed to utilize the growing publicly available biological annotation, chemical screening, RNA interference screening, expression, amplification and 3D structural data. Scientists can, in a single place, rapidly identify biological annotation of a target, its structural characterization, expression levels and protein interaction data, as well as suitable cell lines for experiments, potential tool compounds and similarity to known drug targets. canSAR has, from the outset, been completely use-case driven which has dramatically influenced the design of the back-end and the functionality provided through the interfaces. The Web interface at http://cansar.icr.ac.uk provides flexible, multipoint entry into canSAR. This allows easy access to the multidisciplinary data within, including target and compound synopses, bioactivity views and expert tools for chemogenomic, expression and protein interaction network data.
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U2 - 10.1093/nar/gkr881
DO - 10.1093/nar/gkr881
M3 - Article
C2 - 22013161
AN - SCOPUS:84860492047
SN - 0305-1048
VL - 40
SP - D947-D956
JO - Nucleic acids research
JF - Nucleic acids research
IS - D1
ER -