Abstract
T cells engineered to express chimeric antigen receptors (CARs) have revolutionised the field of cellular therapy for cancer. Despite its success, this strategy has some recognised limitations and toxicities. Hence, there is growing interest in developing novel cellular therapies based on non-αβ T-cell immune effector cells, including NK cells that offer clear advantages in cancer immunotherapy. As a result, NK cells are being explored as an alternative platform for CAR engineering and are becoming recognised as important players in the next generation of cellular therapies targeting cancer. In this review, we highlight preclinical and clinical studies of CAR-NK cells derived from different sources and discuss strategies under investigation to enhance the antitumor activity of these engineered innate immune cells.
Original language | English (US) |
---|---|
Article number | e1274 |
Journal | Clinical and Translational Immunology |
Volume | 10 |
Issue number | 4 |
DOIs | |
State | Published - 2021 |
Keywords
- CAR
- NK cells
- allogeneic
- cancer immunotherapy
- cellular therapy
- off-the-shelf product
ASJC Scopus subject areas
- General Nursing
- Immunology and Allergy
- Immunology