Carcinoid tumors of the lung and family history of cancer

Penny Perkins, Ju Ruey Jiuan Lee, Bonnie L. Kemp, James D Cox

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Family history of cancer has been described among patients with lung neoplasms. Carcinoid tumors, originally thought to be slow growing and nonmetastatic, have not historically been included in these studies. In some instances these tumors have demonstrated aggressive metastatic potential. A medical record review of 86 patients with histopathologically confirmed carcinoid tumors of the lung, treated at the University of Texas M.D. Anderson Cancer Center between 1959 and 1994, was conducted to describe family history of cancer. Family history of cancer was recorded in 74 (86%) of the medical records and 32 (43%) reported first-degree relatives with cancer. Five-year survival for patients with affected relatives was 45% and 73% for patients without affected relatives IP = .23). Among 67 patients without metastatic disease at diagnosis, the risk of distant metastasis by 5 years was 40% among patients with a positive family history of cancer compared to 6% of the patients without affected relatives (p = .03), (rate ratio 5.01). These results suggest that genetic susceptibility may affect the metastatic potential of some carcinoid tumors.

Original languageEnglish (US)
Pages (from-to)705-709
Number of pages5
JournalJournal of clinical epidemiology
Volume50
Issue number6
DOIs
StatePublished - Aug 26 1997

Keywords

  • Carcinoid
  • Family history
  • Lung cancer
  • Metastasis

ASJC Scopus subject areas

  • Epidemiology

Fingerprint Dive into the research topics of 'Carcinoid tumors of the lung and family history of cancer'. Together they form a unique fingerprint.

  • Cite this