Case of mediastinal epithelioid hemangioendothelioma associated with hypertrophic osteoarthropathy and literature review

Research output: Contribution to journalArticle

Abstract

Hypertrophic osteoarthropathy is commonly associated with malignancies of the lungs and stomach. A few cases associated with epithelioid hemangioendothelioma, a rare vascular soft tissue neoplasm, have been reported. Presented here is the first report of a case of hypertrophic osteoarthropathy as the initial symptom of epithelioid hemangioendothelioma of the mediastinum. A 64-year-old woman presented with pain around the long bones and diffuse puffiness of bilateral hands and feet. She had a history of multiple malignancies, all of which were in remission. She had clubbing of her fingernails and toenails. Her chest X-ray was negative. A positron emission tomography (PET) scan performed showed metabolically active soft tissue that extensively infiltrated the mediastinum, with several sites of disease involving the pericardium. Mediastinal biopsy and subsequent pleural fluid cytology obtained by thoracocentesis was consistent with metastatic epithelioid hemangioendothelioma. Our case supports that the PET scan has a valuable role in localizing malignancies in such patients who present with hypertrophic osteoarthropathy and no lung or stomach involvement.

Original languageEnglish (US)
Pages (from-to)457-460
Number of pages4
JournalThoracic Cancer
Volume4
Issue number4
DOIs
StatePublished - Nov 1 2013

Fingerprint

Epithelioid Hemangioendothelioma
Mediastinum
Nails
Positron-Emission Tomography
Stomach
Soft Tissue Neoplasms
Vascular Tissue Neoplasms
Neoplasms
Lung
Pericardium
Cell Biology
Foot
Thorax
Hand
X-Rays
Biopsy
Bone and Bones
Pain

Keywords

  • Epithelioid
  • Hemangioendothelioma
  • Mediastinum
  • Osteoarthropathy
  • Secondary hypertrophic

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

@article{6408b4f8c0274faba60c2a95cc4c965a,
title = "Case of mediastinal epithelioid hemangioendothelioma associated with hypertrophic osteoarthropathy and literature review",
abstract = "Hypertrophic osteoarthropathy is commonly associated with malignancies of the lungs and stomach. A few cases associated with epithelioid hemangioendothelioma, a rare vascular soft tissue neoplasm, have been reported. Presented here is the first report of a case of hypertrophic osteoarthropathy as the initial symptom of epithelioid hemangioendothelioma of the mediastinum. A 64-year-old woman presented with pain around the long bones and diffuse puffiness of bilateral hands and feet. She had a history of multiple malignancies, all of which were in remission. She had clubbing of her fingernails and toenails. Her chest X-ray was negative. A positron emission tomography (PET) scan performed showed metabolically active soft tissue that extensively infiltrated the mediastinum, with several sites of disease involving the pericardium. Mediastinal biopsy and subsequent pleural fluid cytology obtained by thoracocentesis was consistent with metastatic epithelioid hemangioendothelioma. Our case supports that the PET scan has a valuable role in localizing malignancies in such patients who present with hypertrophic osteoarthropathy and no lung or stomach involvement.",
keywords = "Epithelioid, Hemangioendothelioma, Mediastinum, Osteoarthropathy, Secondary hypertrophic",
author = "Pundole, {Xerxes Nozer} and Huifang Lu",
year = "2013",
month = "11",
day = "1",
doi = "10.1111/j.1759-7714.2012.00170.x",
language = "English (US)",
volume = "4",
pages = "457--460",
journal = "Thoracic Cancer",
issn = "1759-7706",
publisher = "Blackwell Publishing Asia Pty Ltd",
number = "4",

}

TY - JOUR

T1 - Case of mediastinal epithelioid hemangioendothelioma associated with hypertrophic osteoarthropathy and literature review

AU - Pundole, Xerxes Nozer

AU - Lu, Huifang

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Hypertrophic osteoarthropathy is commonly associated with malignancies of the lungs and stomach. A few cases associated with epithelioid hemangioendothelioma, a rare vascular soft tissue neoplasm, have been reported. Presented here is the first report of a case of hypertrophic osteoarthropathy as the initial symptom of epithelioid hemangioendothelioma of the mediastinum. A 64-year-old woman presented with pain around the long bones and diffuse puffiness of bilateral hands and feet. She had a history of multiple malignancies, all of which were in remission. She had clubbing of her fingernails and toenails. Her chest X-ray was negative. A positron emission tomography (PET) scan performed showed metabolically active soft tissue that extensively infiltrated the mediastinum, with several sites of disease involving the pericardium. Mediastinal biopsy and subsequent pleural fluid cytology obtained by thoracocentesis was consistent with metastatic epithelioid hemangioendothelioma. Our case supports that the PET scan has a valuable role in localizing malignancies in such patients who present with hypertrophic osteoarthropathy and no lung or stomach involvement.

AB - Hypertrophic osteoarthropathy is commonly associated with malignancies of the lungs and stomach. A few cases associated with epithelioid hemangioendothelioma, a rare vascular soft tissue neoplasm, have been reported. Presented here is the first report of a case of hypertrophic osteoarthropathy as the initial symptom of epithelioid hemangioendothelioma of the mediastinum. A 64-year-old woman presented with pain around the long bones and diffuse puffiness of bilateral hands and feet. She had a history of multiple malignancies, all of which were in remission. She had clubbing of her fingernails and toenails. Her chest X-ray was negative. A positron emission tomography (PET) scan performed showed metabolically active soft tissue that extensively infiltrated the mediastinum, with several sites of disease involving the pericardium. Mediastinal biopsy and subsequent pleural fluid cytology obtained by thoracocentesis was consistent with metastatic epithelioid hemangioendothelioma. Our case supports that the PET scan has a valuable role in localizing malignancies in such patients who present with hypertrophic osteoarthropathy and no lung or stomach involvement.

KW - Epithelioid

KW - Hemangioendothelioma

KW - Mediastinum

KW - Osteoarthropathy

KW - Secondary hypertrophic

UR - http://www.scopus.com/inward/record.url?scp=84886997142&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886997142&partnerID=8YFLogxK

U2 - 10.1111/j.1759-7714.2012.00170.x

DO - 10.1111/j.1759-7714.2012.00170.x

M3 - Article

AN - SCOPUS:84886997142

VL - 4

SP - 457

EP - 460

JO - Thoracic Cancer

JF - Thoracic Cancer

SN - 1759-7706

IS - 4

ER -