Caspofungin-resistant Candida tropicalis strains causing breakthrough fungemia in patients at high risk for hematologic malignancies

Guillermo Garcia-Effron; Dimitrios P. Kontoyiannis; Russell E. Lewis; David S. Perlin

doi:10.1128/AAC.00802-08

Caspofungin-resistant Candida tropicalis strains causing breakthrough fungemia in patients at high risk for hematologic malignancies

Guillermo Garcia-Effron
, Dimitrios P. Kontoyiannis
, Russell E. Lewis
, David S. Perlin

Infectious Diseases, Infection Control, and Employee Health

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

Abstract

We identified three cases of C. tropicalis strains causing breakthrough fungemia in allogeneic stem cell recipients receiving caspofungin prophylaxis and treatment. Three genetically unrelated isolates with high echinocandin MICs were identified. Each strain carried a characteristic mutation conferring an amino acid substitution within Fks1p hot spot 1.

Original language	English (US)
Pages (from-to)	4181-4183
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	52
Issue number	11
DOIs	https://doi.org/10.1128/AAC.00802-08
State	Published - Nov 2008

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "Caspofungin-resistant Candida tropicalis strains causing breakthrough fungemia in patients at high risk for hematologic malignancies",

abstract = "We identified three cases of C. tropicalis strains causing breakthrough fungemia in allogeneic stem cell recipients receiving caspofungin prophylaxis and treatment. Three genetically unrelated isolates with high echinocandin MICs were identified. Each strain carried a characteristic mutation conferring an amino acid substitution within Fks1p hot spot 1.",

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AU - Garcia-Effron, Guillermo

AU - Kontoyiannis, Dimitrios P.

AU - Lewis, Russell E.

AU - Perlin, David S.

PY - 2008/11

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AB - We identified three cases of C. tropicalis strains causing breakthrough fungemia in allogeneic stem cell recipients receiving caspofungin prophylaxis and treatment. Three genetically unrelated isolates with high echinocandin MICs were identified. Each strain carried a characteristic mutation conferring an amino acid substitution within Fks1p hot spot 1.

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AN - SCOPUS:55849137651

SN - 0066-4804

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JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

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ER -

Caspofungin-resistant Candida tropicalis strains causing breakthrough fungemia in patients at high risk for hematologic malignancies

Abstract

ASJC Scopus subject areas

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